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EC number: 211-477-1 | CAS number: 647-42-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Remarks:
- Conducted according to guideline in effect at time of study conduct
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctan-1-ol
- EC Number:
- 211-477-1
- EC Name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctan-1-ol
- Cas Number:
- 647-42-7
- Molecular formula:
- C8H5F13O
- IUPAC Name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctan-1-ol
- Details on test material:
- - Purity: 99.7%
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Replicate A, all test concentrations including the dilution water control, day 0, day 2 renewal (old and new), day 4 old.
- Sampling method: LC/MS analysis
- Sample storage conditions before analysis: refrigerated upon receipt and when not in use.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION:
Test solutions were prepared by adding the appropriate volume of the test material to the appropriate volume of Haskell Well Water in 4 L Erlenmeyer flasks filled to attain zero headspace (final volume approximately 4.3L) and sonicating for approximately 20 minutes, stirring for approximately 20 minutes, then repeating the sonicating and stirring for two additional cycles, for a total mixing time of approximately 2 hours. The dilution water control and all test solutions were clear and colourless with no visible precipitate.
Test organisms
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Age at study initiation: >112 days
- Feeding during test: no
ACCLIMATION PERIOD: no
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- none
Test conditions
- Hardness:
- - Total Alkalinity: 49 mg/L as CaCO3
- EDTA Hardness: 116 mg/L as CaCO3 - Test temperature:
- 21.4 to 21.6°C
- pH:
- Dilution Water Control: 7.0 - 7.3
- Dissolved oxygen:
- Dilution Water Control: 5.4 - 8.5 mg/L
- Salinity:
- freshwater
- Nominal and measured concentrations:
- Nominal concentrations: 0, 1.0, 2.0, 4.0, 8.0, and 16.0 mg/L
Measured concentrations: 0, 0.751, 1.61, 3.12, 7.52 and 16.4 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 4-L Erlenmeyer flasks
- Renewal rate of test solution (frequency/flow rate): renewed at day 2 (48 hours)
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS: Water quality parameters were determined to be within acceptable limits.
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Mortality and sublethal effect observations were made at test start, every 24 hours thereafter, and at test end.
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light and 8 hours darkness, which included 30 minutes of transitional light (3-125 Lux) preceding and following the 16-hour light interval.
- Light intensity: approximately 126-710 Lux
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 4.84 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% confidence limits of 3.12 to 7.52 mg/L
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 3.12 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 7.52 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: none observed
- Observations on body length and weight: Fish in the dilution water control ranged from 2.2 to 2.8 cm in standard length and 0.140 to 0.304 g in wet weight, blotted dry, at test end.
- Mortality of control: none
- Mortality of mean measured test concentrations: 100% mortality at 7.52, and 16.4 mg/L - Reported statistics and error estimates:
- 96-hour LC50 values and confidence limits were calculated by the binomial method based on mean, measured concentrations of the test substance and mortality. The highest mean, measured concentration causing no mortality at test end and the lowest mean, measured concentration causing 100% mortality at test end were assessed by visual observation.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).
96-h LC50 = 4.84 mg/L
96-h NOEC = 3.12 mg/L.
96-h LC100 = 7.52 mg/L. - Executive summary:
The acute toxicity of the test substance to unfed juvenile fathead minnow, Pimephales promelas, was determined in an unaerated, static-renewal 96-hour toxicity test. The study was conducted with 5 concentrations of the test substance and a dilution water control at a mean temperature of 23.0°C (range of 21.5-26.0°C). The test solutions were renewed once after 48 hours. Two replicate test chambers were used per test concentration with 5 fish in each chamber (10 fish per concentration). Exposure of fathead minnow to mean, measured test substance concentrations of 0.751, 1.61, 3.12, 7.52, and 16.4 mg/L resulted in 0, 0, 0, 100, and 100% mortality, respectively, at the end of 96 hours. No mortality or sublethal effects were seen in the dilution water control fish. Mean, measured concentrations ranged from 75 to 103% of the nominal concentrations. The highest mean, measured concentration causing no mortality at test end was 3.12 mg/L. The lowest mean, measured concentration causing 100% mortality at test end was 7.52 mg/L. Mean, measured concentrations of the test substance were used for calculation of LC50 values. The 96-hour LC50, based on the mean, measured concentrations of the test substance and mortality, was 4.84 mg/L.
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