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EC number: 203-236-4 | CAS number: 104-78-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
3-aminopropyldiethylamine was shown to be corrosive to the skin and eye and irritating to the respiratory tract.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02. May 1961 - 19. May 1961
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented report which meets basic scientific principles.
- Principles of method if other than guideline:
- Two animals were treated for 1, 5, 15 min using occlusive conditions. An application site of 2.5x2.5 cm was covered with the liquid test substance. After the application time (1, 5, 15 min) the skin was washed with Lutrol (conc.) and Lutrol/water (1:1). The animals were observed for 8 days and skin changes were recorded daily. The report describes findings after 24 hours and at the end of the observation period (8 days). For a final evaluation, the findings after 48 and 72 hours from the raw data were taken into account.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.02 and 2.31 kg - Type of coverage:
- occlusive
- Preparation of test site:
- other: intact skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- 1 min, 5 min and 15 min
- Observation period:
- 14 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: 2.5x2.5 cm
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The skin was washed with Lutrol (conc.) and Lutrol/water (1:1)
- Time after start of exposure: 1, 5 or 15 min
- Irritation parameter:
- other: Necrosis
- Time point:
- other: 24 h to 8 day
- Reversibility:
- not reversible
- Remarks on result:
- other: Exposure time: 1, 5 or 15 min
- Interpretation of results:
- Category 1A (corrosive)
- Executive summary:
Two animals were treated for 1, 5, 15 min using occlusive conditions with 3-aminopropyldiethylamine. An application site of 2.5x2.5 cm was covered with the liquid test substance. After the application time (1, 5, 15 min) the skin was washed with Lutrol (conc.) and Lutrol/water (1:1). The animals were observed for 8 days and skin changes were recorded daily. The report describes findings after 24 hours and at the end of the observation period (8 days). For a final evaluation, the findings after 48 and 72 hours from the raw data were taken into account. Twenty-four hours after the 1, 5 or 15-min exposure, leather-like brown-reddish necrosis with partly reddish partly anaemic surroundings was observed. Eight days post application hard, almost black necrosis was observed.
Reference
The application of the test substance caused necrosis to the exposes tissues and therefore a precise evaluation of erythema and edema scores was not possible.
Major findings after 1, 5 or 15 min exposure: After 24 h leather-like brown-reddish necrosis with partly reddish partly anaemic surroundings was observed. 8 days post application hard, almost black necrosis was observed.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03. May 1961 - 12. May 1961
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented report which meets basic scientific principles.
- Principles of method if other than guideline:
- 50 µL of the test substance were applied to the conjunctival sac of one eye in 2 animals. The animals were observed after 10 min, 1 and 3h on the day of treatment and up to 8 days afterwards. Findings were recorded daily. The eyes were not washed out after 24 hours as specified in OECD Guideline 405. The report describes findings after 1 and 24 hours and at the end of the observation period. For final evaluation, the findings after 48 and 72 hours from the raw data were taken into account.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.01 and 3.23 kg - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The adjacent eye served as control treated with 0.9 % NaCl (saline).
- Duration of treatment / exposure:
- single application
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- corrosion/eye leakage
- Remarks on result:
- other: necrosis
- Other effects:
- Gross pathology: 1 animal with invagination of the eye and 1 animal with phanophtalmia.
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Executive summary:
Fifty µL of 3-aminopropyldiethylamine were applied to the conjunctival sac of one eye in 2 animals. The animals were observed after 10 min, 1 and 3h on the day of treatment and up to 8 days afterwards. Findings were recorded daily. The eyes were not washed out after 24 hours.The application of the test substance caused necrosis and suppuration to the eyes and therefore a precise evaluation of edema and iritis scores was not possible. Shortly after exposure (10 min) animals showed bloody eye discharge and corrosion was noted. After 2 days, swelling of the eyelids was observed. Five days post application vessel ingrow (animal 1) and suppuration (animal 2) was noted. Animal 1 was sacrificed ahead of schedule on day 5 (complete leakage of eye).
Reference
The application of the test substance caused necrosis and suppuration to the eyes and therefor a precise evaluation of edema and iritis scores was not possible.
Shortly after exposure (10 min) animals showed bloody eye discharge and corrosion was noted. After 2 days, swelling of the eyelids was observed. 5 days post application vessel ingrow (animal1) and suppuration (animal2) was noted. Animal 1 was sacrificed ahead of schedule on day 5 (complete leakage of eye).
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin Irritation-Corrosion
In vitro studies
To evaluate the potential skin corrosivity of 3-aminopropyldiethylamine, the pH and acidic/alkaline reserve was measured according to the method described by Regnier and Imbert (ATLA, 1992, 20, 457-465) and Froment (Arkema unpublished data, 1993). Under the test conditions, the results are as follow:
Test item |
pH |
log R (acidic/alkaline reserve |
Physical-chemical index (I) I = pH + log R, for pH =7 I = (14 -pH) + log R, for pH < 7 |
3-aminopropyldiethylamine |
11.9 |
1.6 |
13.5 |
According to the method, a substance is considered as potentially corrosive to the skin if at least 2 of the 3 following criteria are fulfilled:
pH= 2.5 or pH =9.5; log R = 0 and/ot I= 10.
3-aminopropyldiethylamine is considered as potentially corrosive to the skin.
In vivo studies
In a key study (BASF, 1961), two animals were treated for 1, 5, 15 min using occlusive conditions with 3-aminopropyldiethylamine. An application site of 2.5x2.5 cm was covered with the liquid test substance. After the application time (1, 5, 15 min) the skin was washed with Lutrol (conc.) and Lutrol/water (1:1). The animals were observed for 8 days and skin changes were recorded daily. The report describes findings after 24 hours and at the end of the observation period (8 days). For a final evaluation, the findings after 48 and 72 hours from the raw data were taken into account. Twenty-four hours after the 1, 5 or 15-min exposure, leather-like brown-reddish necrosis with partly reddish partly anaemic surroundings was observed. Eight days post application hard, almost black necrosis was observed.
In a suporting study (Clouzeau, 1988), the acute dermal irritation of 3-aminopropyldiethylamine was evaluated inalbino rabbits. 0.5 mL of the test substance was applied during 4 hours in 1 rabbit on the right clipped flank. The left untreated flank was used as negative control. The cutaneous reaction was observed one hour, 24, 48, 72 hours after removal of the dressing. After 1 hour, 24, 48 and 72 hours, a tissular necrosis was noted on the site of the cutaneous application. The rabbit has been sacrificed for ethical reasons 72 hours after the end of exposition.
Eye irritation-Corrosion
In vitro studies
To evaluate the potential skin corrosivity of 3-aminopropyldiethylamine, the pH and acidic/alkaline reserve was measured according to the method described by Regnier and Imbert (ATLA, 1992, 20, 457-465) and Froment (Arkema unpublished data, 1993). Under the test conditions, the results are as follow:
Test item |
pH |
log R (acidic/alkaline reserve |
Physical-chemical index (I) I = pH + log R, for pH =7 I = (14 -pH) + log R, for pH < 7 |
3-aminopropyldiethylamine |
11.9 |
1.6 |
13.5 |
According to the method, a substance is considered as potentially corrosive to the eye if at least 2 of the 3 following criteria are fulfilled:
pH= 2.5 or pH =9.5; log R = 0 and /or I= 9.
3-aminopropyldiethylamine is considered as potentially severely irritating to the eye.
In vivo studies
In a key study (BASF, 1961), fifty µL of 3-aminopropyldiethylamine were applied to the conjunctival sac of one eye in 2 animals. The animals were observed after 10 min, 1 and 3 h on the day of treatment and up to 8 days afterwards. Findings were recorded daily. The eyes were not washed out after 24 hours. The application of the test substance caused necrosis and suppuration to the eyes and therefore a precise evaluation of edema and iritis scores was not possible. Shortly after exposure (10 min) animals showed bloody eye discharge and corrosion was noted. After 2 days, swelling of the eyelids was observed. Five days post application vessel ingrow (animal 1) and suppuration (animal 2) was noted. Animal 1 was sacrificed ahead of schedule on day 5 (complete leakage of eye)
Justification for classification or non-classification
According to the harmonised classification and labelling (CLP) approved by the European Union:
- Skin Corr. 1B, H314
- Eye Irrit. 1, H318
- Skin Corr. 1A, H314
- Eye Irrit. 1, H318
- STOT-SE 3, H335
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