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EC number: 245-485-1 | CAS number: 23202-81-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06 December 2012 to 16 July 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Fully GLP compliant and in accordance with current test guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Methylfuranoside
- IUPAC Name:
- Methylfuranoside
- Reference substance name:
- Methyl 5-deoxy-2,3-O-isopropylidene-β-D-ribofuranoside
- EC Number:
- 245-485-1
- EC Name:
- Methyl 5-deoxy-2,3-O-isopropylidene-β-D-ribofuranoside
- Cas Number:
- 23202-81-5
- Molecular formula:
- C9H16O4
- IUPAC Name:
- methyl 5-deoxy-2,3-O-isopropylidene-beta-D-ribofuranoside
- Test material form:
- other: pale yellow liquid
- Details on test material:
- Name: Methylfuranoside
CAS number: 23202-81-5
Batch number: 201111082008
Quantity supplied: 1.5 kg
Purity: 99.7%
Expiry date: November 2013
Date of receipt: 19 November 2012
Appearance: pale yellow liquid
Storage details: stored in a sealed container, at room temperature (15 to 25°C) in the dark.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: HsdHan:WIST
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Ltd, Bicester, UK
- Age at study initiation: 8 to 9 weeks
- Weight at study initiation: weight variation did not exceed ±20% of the mean weight.
- Fasting period before study: from the evening of the day prior to dosing (Day -1) until approximately 3 hours after dosing
- Housing: The animals were housed in groups of up to three during the acclimatisation period in cages that conform to the 'Code of Practice for the Housing and Care of Animals Used in Scientific Procedures' (Home Office, London, 1989).
- Diet (e.g. ad libitum): SQC(E) Rat and Mouse Maintenance Diet No 1, ad libitum
- Water (e.g. ad libitum): Mains water was provided, ad libitum, via cage-mounted water bottles.
- Acclimation period: 8 to 10 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 to 24°C
- Humidity (%): 45 to 65%, On two occasions the minimum relative humidity was 41%. These deviations were considered not to have affected the integrity or outcome of the study.
- Air changes (per hr): 15 to 20 air changes per hour
- Photoperiod (hrs dark / hrs light): illuminated by fluorescent strip-lights for twelve hours daily
IN-LIFE DATES: From: 18 December 2012 To: 04 January 2013
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE: Not Applicable, unchanged (no vehicle)
MAXIMUM DOSE VOLUME APPLIED: 1.80 mL/kg
DOSAGE PREPARATION: The test item was used as supplied. The specific gravity was determined and used to calculate the appropriate dose volume for the required dose level. - Doses:
- 2000 mg/kg (Specific gravity: 1.116 g/mL)
- No. of animals per sex per dose:
- 3 animals per dose group, 2 dose groups
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical signs were recorded immediately post-dose, at approximately 15 and 30 minutes post-dose, hourly between 1 and 4 hours post dose (inclusive), twice daily on Days 2, 3 and 4 and once daily from the fifth to last day of the observation period. Animals 211 to 213 were also observed at 5 and 7 hours post dose on Day 1.
All animals were examined at the beginning and end of the working day throughout the acclimatisation and study periods to ensure they were in good health.
Rats were weighed on Day -1 (day before dosing) and on Days 1, 4, 8 and 15. Decedent carcass weights were also recorded prior to necropsy.
- Necropsy of survivors performed: yes
- Other examinations performed: mortality, clinical signs and body weights - Statistics:
- Not applicable
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One animal was found dead on Day 2.
- Clinical signs:
- other: Two animals showed piloerection only, between 1 and 3 hours after dosing. These animals appeared normal from 4 hours after dosing. Piloerection was also noted in all other animals, with additional signs of prone posture, sunken flanks, decreased breathing
- Gross pathology:
- No abnormalities were noted at necropsy of animals that died or were killed at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The acute median lethal oral dose level of the test article, Methylfuranoside, was found to exceed 2000 mg/kg.
The test material was considered to have no significant acute toxic risk in respect of its acute oral toxicity and did not meet the criteria for classification according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS). - Executive summary:
This study was conducted to assess the acute toxicity of the test item, Methylfuranoside, following a single oral administration to rats.
Groups of three female fasted rats were given the test item as a single dose on Day 1 by oral gavage at dose levels of 2000 mg/kg. The test item was administered as supplied. Surviving animals were killed on Day 15. All animals underwent a full necropsy.
One animal was found dead on Day 2.
Piloerection was also noted in all animals, with additional signs of prone posture, sunken flanks, decreased breathing rate, decreased activity, hunched posture, ataxia, tremors and arched gait. These signs developed from 15 minutes after dosing and lasted up to Day 2.
All surviving rats achieved body weight gains during the first and second weeks of the study.
No abnormalities were noted at necropsy of animals that died or were killed at the end of the study.
The acute median lethal oral dose level of the test article, Methylfuranoside, was found to exceed 2000 mg/kg.
The test material was considered to have no significant acute toxic risk in respect of its acute oral toxicity and did not meet the criteria for classification according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
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