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EC number: 202-645-5 | CAS number: 98-17-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38412, Part II (Daphnia short-time test)
- Version / remarks:
- (German Institute of Standardization, 1982).
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The solutions were prepared with 'dilution water'. The concentration steps were selected so as to give 3-4 EC values in a range between EC0 and EC100, of which at least one value was below and one above EC50.
- Controls: positive control.
- Chemical name of vehicle: dilution water. The dilution water used had a specific composition: acid capacity K(s4.3) of 0.8 mmol/L, total hardness of 2.4 mmol/L, a calcium to magnesium ratio of 4:1, a sodium to potassium ratio of 10:1 and thus a resulting initial pH value of 8.0 ± 0.2.
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): no. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Source: 6-24 h old daphnids, from the laboartory's own culture (Bringrnann and Kühn, 1982)
- Feeding during test: no. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 2.4 mmol/L
- pH:
- 8.0 ± 0.2
- Dissolved oxygen:
- > 4.0 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: two 50 mL beakers.
- Material, size, headspace, fill volume: glass, 50 mL, fill volume 20 mL.
- No. of organisms per vessel: 10. Loading amounted to one test animal per 2 ml test medium as 10 daphnids were placed in each test/control vessel, i.e. 20 animals per step.
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Ca/mg ratio: 4:1
- Culture medium different from test medium: not specified.
OTHER TEST CONDITIONS
- Adjustment of pH: no.
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
VEHICLE CONTROL PERFORMED: no - Reference substance (positive control):
- yes
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 7.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 11 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL: 10-12 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 20 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- 7.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 11 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL: 10-12 mg/L
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- 20 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Remarks:
- The test was considered as valid when fewer than 10% of the animals in the control solutions were unable to swim, when the pH value was not below 7.0 and the O2 value was not below 4.0 mg/L. The values reported were considered valid.
- Conclusions:
- The 48h-EC50 of the test item in Daphnia magna is 11 mg/L.
- Executive summary:
An acute immobilisation test on Daphnia magna was performed in accordance with DIN 38412, Part II (Daphnia short-time test). At least one concentration below and one above the EC50 value were tested in two replicates, each vessel (glass beaker) contained 10 daphnids. A positive control was run in parallel to assess the validity of the study. Based on the effects of the test item in Daphnia magna, the 48h-EC0 was found to be 7.3 mg/L, the EC100 20 mg/L, and the EC50, 11 mg/L.
Reference
Description of key information
Key study. Study according to DIN 38412, Part II (Daphnia short-time test). The 48h-EC50 in daphnia of the test item is 11 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 11 mg/L
Additional information
An acute immobilisation test on Daphnia magna was performed in accordance with DIN 38412, Part II (Daphnia short-time test). At least one concentration below and one above the EC50 value were tested in two replicates, each vessel (glass beaker) contained 10 daphnids. A positive control was run in parallel to assess the validity of the study. Based on the effects of the test item inDaphnia magna,the 48h-EC0 was found to be 7.3 mg/L, the EC100 20 mg/L, and the EC50, 11 mg/L.
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