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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Utilizing the weight of evidence study for skin irritation/corrosion, it is concluded that the chemical 2-nitro-p-toluidine is not likely to cause skin irritation efefct to the skin of rabbit in low concentrations

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Kemi-Riskline database
GLP compliance:
not specified
Species:
rabbit
Strain:
not specified
Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
no data
Remarks on result:
other: no primary irritant effect
Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
2-nitro-p-toluidine is found to be non-irritating to skin of the rabbit.
Executive summary:

2-nitro-p-toluidine is found to be non-irritating to skin of the rabbit.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Kemi-Riskline database
GLP compliance:
not specified
Species:
rabbit
Strain:
not specified
Vehicle:
not specified
Controls:
not specified
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
not specified
Remarks on result:
other: no primary irritant effect
Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
2-nitro-p-toluidine is found to be non-irritating to eye of the rabbit as per the information available in the database of the Swedish chemical agency.
Executive summary:

2-nitro-p-toluidine is found to be non-irritating to eye of the rabbit as per the information available in the database of the Swedish chemical agency.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Data available from authoritative databases indicates that 2-nitro-p-toluidine is unlikely to cause irritation or corrosion effect on the skin of rabbit as also a negative eye irritation effect at low concentration levels. Thus, this chemical is not classified as a skin and eye irritant.

Summary of the skin irritation data available

S. No

Data Source

Value

Species

1

Kemi riskline database

Not irritating

Rabbit

2

Danish EPA database

Not irritating

Rabbit

3

QSAR

Slightly irritating

Rabbit (Peromyscus maniculatus)


Justification for selection of skin irritation / corrosion endpoint:
2-nitro-p-toluidine is found to be non-irritating to skin of the rabbit.

Justification for selection of eye irritation endpoint:
2-nitro-p-toluidine is found to be non-irritating to eye of the rabbit.

Justification for classification or non-classification

Data available from authoritative databases indicates that 2-nitro-p-toluidine is unlikely to cause irritation or corrosion effect on the skin of rabbit as also a negative eye irritation effect at low concentration levels. Thus, this chemical is not classified as a skin and eye irritant.