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EC number: 203-372-4 | CAS number: 106-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05. Jun 1967 - 14. Jun 1967
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- (adopted 1981)
- Deviations:
- yes
- Remarks:
- (7 day observation period; highest dose tested was 1612 mg, but all animals of this dose group - besides one male animal - died)
- Principles of method if other than guideline:
- BASF-Test. The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
A test group consisting of 5 animals/sex was treated by single gavage with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 7 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. The LD50 value was estimated on the basis of the observed mortalities. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Bis(2-ethylhexyl)amine
- EC Number:
- 203-372-4
- EC Name:
- Bis(2-ethylhexyl)amine
- Cas Number:
- 106-20-7
- Molecular formula:
- C16H35N
- IUPAC Name:
- bis(2-ethylhexyl)amine
- Details on test material:
- - Name of test material (as cited in study report): di-(2-aethylhexyl)-amine
- Analytical purity: > 99%
no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: US-rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: male: 254 g (mean), female: 206 g (mean).
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous Traganth solution
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2% (161 mg/kg bw), 20% (806, 1008, 1290, 1612 mg/kg bw)
MAXIMUM DOSE VOLUME APPLIED: 6.25 ml (1250 mg/kg bw), 5 ml (1000 mg/kg bw), 8 ml (1600 mg/kg bw), 10 ml (200 / 2000 mg/kg bw) - Doses:
- 161, 806, 1008, 1290, 1612 mg/kg bw (= 200, 1000, 1250, 1600, 2000 mL/kg bw ; calculation of doses in mg/kg bw by means of density = 0.8062 g/mL)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 008 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Systemic toxicity (including mortality) and local irritation observed; see descritpions below for details
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 149 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 847 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Females appeared to be more sensitive.
- Mortality:
- 1612 mg/kg bw: 1 male died within 24 h. 3 males and 5 females died within 48 h. 4 males died within 7 days. 1 male animal survived.
1290 mg/kg bw: 1 male and 3 females died within 24 h. 2 males and 4 females died within 48 h. 5 males and 5 females died within 7 days.
1008 mg/kg bw: 2 females died within 24 h. 5 females died within 48 h. All males survived.
806 mg/kg bw: 1 female died within 7 days. All other animals survived.
161 mg/kg bw: No animal died. - Clinical signs:
- other: 1612 – 806 mg/kg bw: Irregular / accelerated respiration, heavy ruffled fur, anogenital region smeared with feces (diarrhea), squatting posture, apathy, red eye and nose crusts. The survivors recovered. 161 mg/kg bw: Same but less distinct symptoms as in
- Gross pathology:
- dead animals (806 - 1612 mg/kg bw): Dilated stomach in 18 cases, atony in 8 cases, and blood smeared snouts.
sacrificed animals: Uneven faded liver, adhesion between liver, stomach, spleen and left kidney; bronchitis, bronchopneumonia with emphysema.
Any other information on results incl. tables
Mortality
Dose (mg/kg bw) | Gender | 1 h | 24 h | 48 h | 7 days | ||
1612 | male | 0/5 | 1/5 | 3/5 | 4/5 | ||
female | 0/5 | 0/5 | 5/5 | 5/5 | |||
1290 | male | 0/5 | 1/5 | 2/5 | 5/5 | ||
female | 0/5 | 3/5 | 4/5 | 5/5 | |||
1008 | male | 0/5 | 0/5 | 0/5 | 0/5 | ||
female | 0/5 | 2/5 | 5/5 | 5/5 | |||
806 | male | 0/5 | 0/5 | 0/5 | 0/5 | ||
female | 0/5 | 0/5 | 0/5 | 1/5 | |||
161 | male | 0/5 | 0/5 | 0/5 | 0/5 | ||
female | 0/5 | 0/5 | 0/5 | 0/5 |
The test substance caused systemic toxicity (including mortality) and local irritation in a dose dependent manner.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The study on acute oral toxicity of Di-2-ethylhexylamin in male and female US-rats resulted in a LD50 value for both sexes of 1008 mg/kg bw. The female animals appeared to be more sensitive. A classification according to the CLP Regulation (EC) No. 1272/2008 (EU-GHS: Cat. 4) is required.
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