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EC number: 620-341-4 | CAS number: 61358-25-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 Nov 2011 – 13 Jan 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to EU and OECD methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: European Commission technical guidance document, June 1996
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Version / remarks:
- adopted in 1981
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Department of Health, UK GLP Monitoring Authority (2011)
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- bis(4-tert-butylphenyl)iodanium; hexafluoro-λ⁵-phosphanuide
- EC Number:
- 620-341-4
- Cas Number:
- 61358-25-6
- Molecular formula:
- C20H26F6IP
- IUPAC Name:
- bis(4-tert-butylphenyl)iodanium; hexafluoro-λ⁵-phosphanuide
- Details on test material:
- - Name of test material (as cited in study report): PF-6
- Physical state: white powder
- Analytical purity: 99.2 %
- Batch No.: 20101020
- Expiration date of the batch: 12 April 2012
- Storage condition of test material: In the dark, at room temperature
Constituent 1
Results and discussion
Particle size
- Percentile:
- D50
- Remarks on result:
- other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
Particle size distribution at different passagesopen allclose all
- No.:
- #1
- Size:
- < 100 µm
- Distribution:
- 50.3 %
- Remarks on result:
- other: screening test
- No.:
- #2
- Size:
- < 10 µm
- Distribution:
- 0.783 %
- Remarks on result:
- other: cumulative percentage, mean of 3 determinations
- No.:
- #3
- Size:
- < 5.5 µm
- Distribution:
- 0.212 %
- Remarks on result:
- other: cumulative percentage, mean of 3 determinations
Any other information on results incl. tables
Screening test (sieve method)
The results of the sieving procedure are shown in the following
table:
Measurement |
Result |
Mass of test item transferred to sieve |
1607 g |
Mass of test item passed through sieve |
8.09 g |
Proportion of test item < 100 µm |
50.3 % |
Definitive test (cascade impactor method)
The results of the cascade impactor method determinations are shown as follows:
Determination 1 |
||||
Collection |
Particle Size Range |
Mass (g) |
||
|
Pre-sampling |
Post-sampling |
Difference |
|
Cup 1 |
>10.0 |
86.1227 |
89.1431 |
3.0204 |
Cup 2 |
5.5 to 10.0 |
85.5586 |
85.5846 |
0.0260 |
Cup 3 |
2.4 to 5.5 |
85.9064 |
85.9109 |
00045 |
Cup 4 |
1.61 to 2.4 |
85.6891 |
85.6902 |
0.0011 |
Cup 5 |
0.307 to 1.61 |
85.8601 |
85.8606 |
0.0005 |
Filter |
< 0.307 |
75.5584 |
75.5600 |
0.0016 |
Mass of test item found in artificial throat: 0.06 g.
Total mass of test item recovered from artificial throat, sample cups and filter: 3.1141 g.
Determination 2 |
|||||
Collection |
Particle Size Range |
Mass (g) |
|||
|
|
|
Pre-sampling |
Post-sampling |
Difference |
Cup 1 |
>10.0 |
86.1232 |
88.9498 |
2.8266 |
|
Cup 2 |
5.5 to 10.0 |
85.5581 |
85.5744 |
0.0163 |
|
Cup 3 |
2.4 to 5.5 |
85.9066 |
85.9102 |
0.0036 |
|
Cup 4 |
1.61 to2.4 |
85.6883 |
85.6895 |
0.0012 |
|
Cup 5 |
0.307 to 1.61 |
85.8601 |
85.8604 |
0.0003 |
|
Filter |
< 0.307 |
75.5609 |
75.5622 |
0.0013 |
|
Mass of test item found in artificial
throat: 0.15 g.
Total mass of test item recovered from artificial throat, sample cups
and filter: 2.9993 g.
Determination 3 |
||||
Collection |
Particle Size Range |
Mass (g) |
||
|
|
Pre-sampling |
Post-sampling |
Difference |
Cup 1 |
>10.0 |
86.1231 |
88.8464 |
27233 |
Cup 2 |
5.5 to 10.0 |
85.5584 |
85.5689 |
0.0105 |
Cup 3 |
2.4 to 5.5 |
85.9070 |
85.9101 |
0.0031 |
Cup 4 |
1.61 to2.4 |
85.6885 |
85.6898 |
0.0013 |
Cup 5 |
0.307 to 1.61 |
85.8600 |
85.8602 |
0.0002 |
Filter |
< 0.307 |
75.5631 |
75.5640 |
0.0009 |
Mass of test item found in artificial
throat: 0.39 g.
Total mass of test item recovered from artificial throat, sample cups
and filter: 3.12939.
Cumulative amounts
The cumulative amounts of test item found in the three
determinations for the individual particle size cut-points are shown in
the following table:
Particle Size |
Cumulative Mass (g) |
Cumulative Percentage (%) |
||||
|
Determination |
Determination |
Determination |
Determination |
Determination |
Determination |
10.0 |
0.0337 |
0.0227 |
0.0160 |
1.08 |
0.757 |
0.511 |
5.5 |
0,0077 |
0.0064 |
0.0055 |
0.247 |
0.213 |
0.176 |
2.4 |
0.0032 |
0.0028 |
0.0024 |
0.103 |
9.34 x 10-2 |
7.67 x 10-2 |
1.61 |
0.0021 |
0.0016 |
0.0011 |
6.74 x 10-2 |
5,34 x 10-2 |
3.52 x 10-2 |
0.307 |
0.0016 |
0.0013 |
0.0009 |
5.14 x 10-2 |
4.33 x 10-2 |
2.88 x 10-2 |
The overall cumulative percentage of test item with a particle size less than 10.0 µm and 5.5 µm are shown in the following table:
Particle size |
Cumulative Percentage (%) |
|||
|
Determination 1 |
Determination 2 |
Determination 3 |
Mean |
< 10.0 µm |
1.08 |
0.757 |
0.511 |
0.783 |
< 5.5 µm |
0.247 |
0.213 |
0.176 |
0.212 |
Discussion
Too few particles were of a size less than 10.0 µm to allow
accurate assessment of the mass median aerodynamic diameter.
Sampling for the cascade impactor
determinations was performed by rolling the test item container for
approximately 10 minutes then sampled from the top, middle and bottom.
The inhalable fraction is defined as the mass fraction of particles which can be inhaled by nose or mouth, the thoracic fraction is defined as the mass fraction of particles that passes the larynx and the respirable fraction is defined as the mass fraction of particles that reaches the alveoli.
Applicant's summary and conclusion
- Conclusions:
- The particle size distribution of PF-6 was determined using the sieve method (screening test) and the cascade impactor method (definitive test): 50.3 wt-% had an inhalable particle size < 100 µm, 0.783 wt-% had a thoracic particle size < 10 µm and 0.212 % had a respirable particle size < 5.5 µm.
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