Registration Dossier
Registration Dossier
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EC number: 222-376-7 | CAS number: 3452-97-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Nonan-1-ol
- EC Number:
- 205-583-7
- EC Name:
- Nonan-1-ol
- Cas Number:
- 143-08-8
- Molecular formula:
- C9H20O
- IUPAC Name:
- Nonan-1-ol
- Details on test material:
- No further information available.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- cf. chapter 7.5.3
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 6 - 7 h
- Remarks on duration:
- per day
- Concentrations:
- up to max. achievable vapor concentrations at chamber temperature 21-27°C
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The vapor pressure of long chain aliphatic alcohols with carbon chain lengths of C5 and more, including 1-nonanol, is too low to reach vapor concentrations that cause toxicity following single or repeated inhalation exposure (6 or 7 h/day, days 1-19 of gestation in combined repeated toxicity/reproduction toxicity study; cf. chapter 7.5.3).
It is concluded that this finding does also apply for structurally similar test substances, isononanol or 3,5,5-trimethylhexan-1-ol. - Executive summary:
There was no inhalation toxicity seen in rats exposed to higher aliphatic alcohols. It was concluded that the vapor pressure of long chain aliphatic alcohols with carbon chain lengths of C5 and more, including 1 -octanol, 1-nonanol, and 1 -decanol, is too low to reach vapor concentrations that cause toxicity following single or repeated inhalation exposure (6 or 7 h/day, days 1-19 of gestation in a combined repeated toxicity/reproduction toxicity study) (Nelson et al., 1990; cf. chapter 7.5.3).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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