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EC number: 689-137-0 | CAS number: 247569-56-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 2013 - July 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study has been performed according to OECD and/or EC guidelines and according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-fluoro-5-methanesulfonylbenzoic acid
- EC Number:
- 689-137-0
- Cas Number:
- 247569-56-8
- Molecular formula:
- C8 H7 F O4 S
- IUPAC Name:
- 2-fluoro-5-methanesulfonylbenzoic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- BMG sample no. M1302-01397-01
Lot no. 270002C
CAS no. 247569-56-8
Purity 99.86%; treated as 100% pure
Water solubility Soluble
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Results and discussion
Any other information on results incl. tables
Effects on mobility
After 24 and 48 h of exposure, no significant effects (≤10% of immobilization) were observed at the
nominal concentration of 100 mg/l and in the control.
Immobility data are presented in Table 3.
Estimation of EC50and NOEC
The median effect concentration (EC50) with respect to immobilization was estimated to be >100 mg/l
nominal concentration and >68.1 and >67.9 mg/l geometric mean concentrations over a period of 0-24
(GM0-24h) and 0-48 (GM0-48h) of exposure, respectively, of 2-Fluoro-5-(methylsulfonyl)benzoic acid.
The no observed effect concentration (NOEC) was ≥100 mg/l nominal concentration and ≥68.1 and ≥67.9
mg/l geometric mean concentrations over a period of 0-24 (GM0-24h) and 0-48 h (GM0-48h) of
exposure, respectively, of 2-Fluoro-5- (methylsulfonyl)benzoic acid.
100% of immobilization was not observed.
pH-values and oxygen concentrations
pH-values and oxygen concentrations are presented in Table 4. The temperature during the whole test
period remained constant at 21.0°C (target: 20±2°C). All values were within the acceptable range.
Test concentrations
HPLC analyses of 2-Fluoro-5-(methylsulfonyl)benzoic acid were performed at the beginning, after 24
h, and at the end of the exposure (48 h) (Table 5). The test concentration measured at the
beginning of the exposure was 71.3 mg/l. The measured concentrations after 24 and 48 h of exposure
were 66.2 and 66.8 mg/l, and 68.1 and 67.2 mg/l, respectively. The geometric mean concentrations
over a period of 24 (GM0-24h) and 48 h (GM0-48h) were 68.1 mg/l (95% of initial
concentration) and 67.9 mg/l (95% of initial concentration), respectively. The evaluation of the
test was based on the geometric mean (GM) concentrations.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- 100% of immobilization was not observed.
- Executive summary:
The effective concentrations (EC10, EC20, EC50) of 2-Fluoro-5-(methylsulfonyl)benzoic acid to
Daphnia magna were investigated under static exposure conditions over a period of 48 h.
40 individual Daphnia divided into 2 test vessels were exposed to the test substance.
The only applied nominal test concentration was 100 mg/l. Since 2-Fluoro-5- (methylsulfonyl)benzoic
acid is soluble in water, a 100 mg/l stock solution of the test material was directly prepared in
Daphnia medium.
HPLC analyses of 2-Fluoro-5-(methylsulfonyl)benzoic acid were performed at the beginning, after 24
h, and at the end of the exposure (48 h). The test concentration measured at the beginning of the
exposure was 71.3 mg/l. The measured concentrations after 24 and 48 h of exposure were 66.2 and
66.8 mg/l, and 68.1 and 67.2 mg/l, respectively. The geometric mean concentrations over a period of 24 (GM0-24h) and 48 h
(GM0-48h) were 68.1 mg/l (95% of initial concentration) and 67.9 mg/l (95% of initial
concentration), respectively. The evaluation of the test was based on the geometric mean (GM)
concentrations.
After 24 and 48 h of exposure, no significant effects (≤10% of immobilization) were observed at the
nominal concentration of 100 mg/l and in the control.
The median effect concentration (EC50) with respect to immobilization was estimated to be >100 mg/l
nominal concentration and >68.1 and >67.9 mg/l geometric mean concentrations over a period of 0-24
(GM0-24h) and 0-48 h (GM0-48h) of exposure, respectively, of 2-Fluoro-5-(methylsulfonyl)benzoic
acid.
The no observed effect concentration (NOEC) was ≥100 mg/l nominal concentration and ≥68.1 and ≥67.9
mg/l geometric mean concentrations over a period of 0-24 (GM0-24h) and 0-48 h (GM0-48h) of
exposure, respectively, of 2-Fluoro-5- (methylsulfonyl)benzoic acid.
100% of immobilization was not observed.
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