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EC number: 293-927-7 | CAS number: 91648-65-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study. No GLP compliance is claimed, however, the final report includes an audit and quality assurance inspections. The test chamber concentration was not measured analytically.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not applicable
- GLP compliance:
- no
- Remarks:
- The final report includes an audit and quality assurance inspections.
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- not specified
- Details on test material:
- - Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: King Animal Labs, Oregon, Wisconsin
- Age at study initiation: not reported
- Weight at study initiation: males (mean) 271g; females (mean) 197g
- Fasting period before study: no
- Housing: housed in groups of 3 per sex for one week prior to study initiation; for a further 2 weeks prior to study initiation the animals were individually in suspended, stainless steel cages (25 x 17.8 x 17.8 cm). During inhalation exposure the rats were individually housed in perforated metal exposure cages measuring 25 x 8 x 8 cm. Following exposure the rats were transferred into stainless steel cages measuring 18.4 x 16.5 x 15.9 cm
- Diet: Purina Rodent Chow 5001 (Ralston Purina Co.) ad libitum
- Water: ad libitum
- Acclimation period: 3 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22
- Humidity (%): 40
- Photoperiod (hrs dark / hrs light): 12 /12
IN-LIFE DATES:
From 3 February 1981 to 17 February 1981
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- The generating system consisted of a 2000 mL, 3-neck flask (Ace Glass #6947-40) containing 1L of the test article. A mineral bath (Model 220, National Appliance Co., Portland, Oregon) was heated to the desired temperature prior to immersing the test article flask. Air entered the flask via a gas dispersion tube (Ace Glass #7202-16, pore size 25-50 µm). The middle neck of the flask contained a thermometer for measuring the temperature of the test article. Air bubbles carried the test article vapour upward via a 105° elbow (Ace Glass #5075-10) into the exposure chamber. The entire air flow of the chamber passed through the generator flask.
The 50 x 24.3 x 30 cm (37 L) chamber was made of Plexiglas(R). The front of the chamber was removable to facilitate loading and unloading of animals. The test article vapour entered a port at the top of one side of the chamber and exited at the bottom of the opposite side. The vapour was vented into a California type fume hood followed by a filter system. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 2.75 mg/L
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily and more often on the day of dosing
- Necropsy of survivors performed: yes
- Other examinations performed: body weights and necropsies - Statistics:
- No statistical methods are reported.
Results and discussion
- Preliminary study:
- Not applicable.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.75 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortalities during the study.
- Clinical signs:
- other: A clear nasal discharge, red encrustation around nose and eyes, and salivation were observed in four rats following exposure. One male rat exhibited diarrhoea immediately following exposure and on the following day. All remaining rats appeared normal.
- Body weight:
- The mean initial body weights of the male and female rats were 271 g and 197 g, respectively.
- Gross pathology:
- At necropsy, seven rats appeared normal. Three rats had spongy lungs and/or brown foci through all lung lobes.
- Other findings:
- None reported.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The test report describes a valid guideline study, with auditation and quality assurance inspections of the final report. The acute inhalation median lethal concentration (LC50) was estimated to be > 2.75 mg/L. Thus, the test substance can be considered as not acutely toxic via the inhalative route.
- Executive summary:
An acute inhalation study was conducted using a similar procedure to that described in the current OECD Guideline 403 (Findlay, 1981).
The test material (CAS No. 91648-65-6) was administered at 2.75 mg/L by inhalation for 4 h to five male and five female rats. The rats were observed for 14 days after test material administration. No mortalities occurred during the study. The following clinical signs were noted during the study: a clear nasal discharge, red encrustation around nose and eyes, and salivation were observed in four rats following exposure, one male rat exhibited diarrhoea immediately following exposure and on the following day. All remaining rats appeared normal. At necropsy, seven rats appeared normal. Three rats had spongy lungs and/or brown foci through all lung lobes. The acute inhalation median lethal concentration (LC50) was determined to be > 2.75 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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