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EC number: 222-023-7 | CAS number: 3320-83-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: EC guideline B.4.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-chlorophenyl isocyanate
- EC Number:
- 222-023-7
- EC Name:
- 2-chlorophenyl isocyanate
- Cas Number:
- 3320-83-0
- Molecular formula:
- C7H4ClNO
- IUPAC Name:
- 1-chloro-2-isocyanatobenzene
- Details on test material:
- Purity: 99.7%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated flank of the same animals served as control
- Duration of treatment / exposure:
- 4 hr
- Observation period:
- 14 d
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 60 min
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 hours up to 10 days
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 d
- Other effects:
- Moderate necrosis observed in all animals from 24 hours up to 5 days.
From day6 to day 10 slight necrosis was observed.
Labelling requirements: R34
Any other information on results incl. tables
Acute skin irritation test of o-Chlorphenylisocyanat in rabbits (patch test)
Findings of the skin | Examination schedule | Skin irritation scores | ||
Animal Number | ||||
1 | 2 | 3 | ||
0.5 ml o-Chlorphenylisocyanat/ animal | ||||
erythema and eschar formation. oedema formation |
before dosing | E0/0e0 | E0/0e0 | E0/0e0 |
time after removal of the patch (4 hour exposure) | ||||
60 min | E0/0e0 | E0/0e0 | E0/0e0 | |
24 hrs | E4#/0e0 | E4#/0e0 | E4#/0e0 | |
48 hrs | E4#/0e0 | E4#/0e0 | E4#/0e0 | |
72 hrs | E4#/0e0 | E4#/0e0 | E4#/0e0 | |
4 days | E4#/0e0 | E4#/0e0 | E4#/0e0 | |
5 days | E4#/0e0 | E4#/0e0 | E4#/0e0 | |
6 days | E4##/0e0 | E4##/0e0 | E4##/0e0 | |
7 days | E4##/0e0 | E4##/0e0 | E4##/0e0 | |
8 days | E4##/0e0 | E4##*/0e0 | E4##*/0e0 | |
9 days | E4##*/0e0 | E4##*/0e0 | E4##*/0e0 | |
10 days | E4##*/0e0 | E4##*/0e0 | E4##*/0e0 | |
11 days | E0**/0e0 | E0**/0e0 | E0**/0e0 | |
12 days | E0***/0e0 | E0***/0e0 | E0***/0e0 | |
13 days | E0***/0e0 | E0***/0e0 | E0***/0e0 | |
14 days | E0***/0e0 | E0***/0e0 | E0***/0e0 |
0 = no pathological findings
E =erythema/ eschar formation (4=severe erythema (beet redness) to slight preventing erythema reading)
Oe=oedema
# = moderate necrosis
## = slight necrosis
* = laceration
** = peeling, new skin
*** = new skin
Applicant's summary and conclusion
- Executive summary:
In a skin irritation study according OECD Guideline 404 3 male rabbits were exposed for 4 hours to 0.5 ml test substance/ patch and animal under semi-occlusive conditions. The first 60 minutes no effects were observed in all animals.
Beginning at 24hours up to 10 days erythema were observed in all animals. In addition, in all 3 rabbits moderate necrosis was observed 24 hours to 5 days and slight necrosis 6 days to 10 days after patch removal. The rabbit skin showed lacerations 8 to 10 days after patch removal, peeling and new skin at the 11th day and new skin from 12 to 14 days after patch removal.
There were no systemic intolerance reactions.
The test substance causes burns to skin (labeling requirements: R34).
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