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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable publication which meets basic scientic principles; basic data on expermimental design are given.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VII
Author:
Smyth, HF; Carpenter, CP; Weil, CS; Pozzani UC; Striegel JA; Nycum, JS
Year:
1969
Bibliographic source:
Amer. Ind. Hyg. Assoc. J. 30 (1969), 470
Report date:
1969
Reference Type:
publication
Title:
Chemical Burns of the Rabbit Cornea
Author:
Carpenter, CP; Smyth, HF
Year:
1946
Bibliographic source:
Am J Ophthalmol 29, 1363-1372
Report date:
1946

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
pre-guideline study. primary eye irritation test. quantity of test substance applied and scoring system are different from OECD 405 or Draize
GLP compliance:
no
Remarks:
pre-GLP

Test material

Constituent 1
Chemical structure
Reference substance name:
8,9,10-trinorborn-2-ene
EC Number:
207-866-0
EC Name:
8,9,10-trinorborn-2-ene
Cas Number:
498-66-8
Molecular formula:
C7H10
IUPAC Name:
Bicyclo-[2.2.1]-hept-2-ene
Details on test material:
no data

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
other: propylene glycol
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0,5 ml
- Concentration (if solution): no data
Duration of treatment / exposure:
24h
Observation period (in vivo):
24h
Number of animals or in vitro replicates:
5
Details on study design:
comment: not rinsed

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
other: no data
Time point:
other: 24h
Score:
7
Max. score:
10
Remarks on result:
other: indicates severe burn with 0,5 ml of 15% solution

Applicant's summary and conclusion

Interpretation of results:
highly irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
while the criteria used by Smyth et all cannot be directly translated into CLP criteria and the test system does not provide data on reversibility, the rating justifies a GHS classification of 2A (in the UN system)
Executive summary:

in an primary eye irritation test, the test substance was applied in seveal concentrations to the eye of 5 rabbits per dose level for 24h. Immediately after the application period the irritiation effects were scored on a scale of 1 -10. The test substance was rated as 7.