Registration Dossier
Registration Dossier
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EC number: 219-754-9 | CAS number: 2524-03-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 19th to June 10th 1991
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- O,O-dimethyl phosphorochloridothioate
- EC Number:
- 219-754-9
- EC Name:
- O,O-dimethyl phosphorochloridothioate
- Cas Number:
- 2524-03-0
- Molecular formula:
- C2H6ClO2PS
- IUPAC Name:
- O,O-dimethyl chlorophosphonothioate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: SPF albino Mol:Russian
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 3 min, 1 hour, 4 hours thereafter the treated skin was cleaned with soap and lukewarm water.
- Observation period:
- half an hour later.
24, 48, 72 hours after application as well as on day 7, 14, 21 and 28 for some rabbits. - Number of animals:
- 9 animals
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 3 minutes
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 3 minutes
- Score:
- 2.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 2.3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 hour exposure
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 4 hours exposure
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 28 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 4 hours exposure
- Score:
- 3.8
- Max. score:
- 4
- Reversibility:
- fully reversible within: 28 days
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- it must be concluded that the test article shall be classified as skin irritating after 1 hour and 4 hours of exposure, and the test item shall not be classified as corrosive after neither 3 minutes, 1 hour nor 4 hours of exposure.
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