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Diss Factsheets
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EC number: 447-010-5 | CAS number: 670241-72-2 ISONONYLBENZOAT
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The potential of the test item, BENZOlC ACID ISONONYLESTER, to induce and elicit delayed dermal sensitisation was assessed by a guinea pig model using the maximisation test of Magnusson and Kligrnan. The concentrations of the test item used in the main study were detennined by the results of preliminary screening tests. The main sensitisation test was undertaken using a test group of 20 animals and a control group of 10 animals. In an attempt to induce sensitisation, test animals were intradermally injected with an emulsion of Freund's complete adjuvant and the test item at 20% concentration in both the selected vehicle (corn oil) and an emulsion of Freund's complete adjuvant. One week later this was boosted by topical application of the undiluted test item over the injection sites. Control group animals were treated in the same manner but the selected vehicle was used in place of the test item. Two weeks after the second induction stage, all animals were challenged by topical application of both the vehicle and the undiluted test item. At the challenge with the test item at 50% concentration no response to the test item was apparent in any animal of the test or control groups. No reaction to the vehicle alone was observed in any animal. These results indicate that the test item, BENZOIC ACID ISONONYLESTER, does not elicit a sensitisation response in the guinea pig, there being no reaction observed at challenge. European Directives concerning the classification, packaging and labelling of dangerous substances (67/548/EEC and subsequent revisions) would indicate the following: Classification : Not required; Symbol : None indicated; R Phrase : None indicated;
Migrated from Short description of key information:
The potential of the test item, BENZOlC ACID ISONONYLESTER, to induce and elicit delayed dermal sensitisation was assessed by a guinea pig model using the maximisation test of Magnusson and Kligman. The results indicate that the test item, BENZOIC ACID ISONONYLESTER, does not elicit a sensitisation response in the guinea pig, there being no reaction observed at challenge.
Justification for classification or non-classification
EU classification according to Annex VI of Directive 67/548/EEC: no classification required
GHS classification (GHS UN rev.2, 2007): no classification required
At the challenge with the test item at 50% concentration no response to the test item was apparent in any animal of the test or control groups. No reaction to the vehicle alone was observed in any animal. These results indicate that the test item, BENZOIC ACID ISONONYLESTER, does not elicit a sensitisation response in the guinea pig, there being no reaction observed at challenge. European Directives concerning the classification, packaging and labelling of dangerous substances (67/548/EEC and subsequent revisions) would indicate the following: Classification : Not required; Symbol : None indicated; R Phrase : None indicated;
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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