Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 459-330-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03/AUG/04 - 05/NOV/04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Specific details on test material used for the study:
- Asahiklin AE-3000, molecular weight 200.07
CAS 406-78-0
Clear colourless liquid
Batch 50407070
Purity: 99.985%
The test substance was stored in a refrigerator in the dark under stable conditions
The test substance expiry date was the 07 July 2005 - Key result
- Water solubility:
- 837 mg/L
- Incubation duration:
- 24 h
- Temp.:
- 20.1 °C
- pH:
- 9.1
- Key result
- Water solubility:
- 783 mg/L
- Incubation duration:
- 48 h
- Temp.:
- 20.1 °C
- pH:
- 8.5
- Key result
- Water solubility:
- 794 mg/L
- Incubation duration:
- 72 h
- Temp.:
- 20.1 °C
- pH:
- 8.5
- Conclusions:
- The water solubility of 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether at 20.1 ± 0.5 °C was determined to be 0.805g/l using the flask method.
- Executive summary:
An experiment was carried out to determine the water solubility of 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether
. Between 136 and 138 of the test substance was added to 22.5ml of double distilled water in a securely closed GC vial and stirred for either 24, 48 or 72 hours in a climate room. The concentration of
1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether i
n the water samples was then determined. From this, the water solubility (the saturation mass concentration of the test substance in water at a given temperature) of ASAHIKLIN AE-3000 was determined to be 0.805g/l at 20.1 ±0.5°C.
Reference
The water solubility of a test substance is specified by the saturation mass concentration of the test substance in water at a given temperature. To determine the concentration of 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether in the water samples, the following formula was used:
C (g/l) = ((R – b) * d * 10-3) / a
Where:
R = response sample (units)
d = dilution factor
a = slope (units*l/mg)
b= intercept (units) The above values were taken from a calibration curve, which was constructed on each day of analysis using at least 4 concentrations. The response was correlated with the concentration test substance, using linear regression analysis. The coefficient of correlation was always >0.99. Because the water solubility of 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether was <100g/l, no correction for the mass fraction of the test substance in the water mixture needed to be made.
Preliminary test: The concentration of 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether in the aqueous phase prior to/ after the first and second centrifugation steps was 816mg/l, 827mg/l and 819mg/l respectively. From this, it could be safely concluded that the water solubility of
1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether is >10mg/l. Thus, the flask method was chosen for water solubility determination in the main study. The pH of the aqueous phase after the three centrifugation steps was 7.2 Since no significant difference was observed between the concentration analysed before and after centrifugation, it was concluded that no undissolved test substance was present in the aqueous phase. Therefore, it was decided to analyse the aqueous phase without centrifugation in the main study.
Main study: The results for the samples have been summarised in the table below:
Stirring time (hours) |
Concentrations analysed (mg/l) |
Mean concentration (mg/l) |
pH |
24
|
829 |
837 |
9.1 |
845 |
|||
48 |
804 |
783 |
8.5 |
763 |
|||
72 |
794 |
794 |
8.5 |
795 |
|||
|
|
Mean: 805 mg/l |
|
Since the 24-, 48-, and 72 hour measurements are in agreement (max deviation <15%), the water solubility of 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether was calculated as a mean value of all of the measurements (805mg/l at 20.1 ±0.5 °C).
Description of key information
Key value for chemical safety assessment
- Water solubility:
- 0.805 g/L
- at the temperature of:
- 20.1 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.