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EC number: 813-999-0 | CAS number: 59039-15-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From November 6, 2019 to December 31, 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Supplied by Sponsor, Batch no 1910031010R
- Expiration date of the lot/batch: 3 October 2020
- Purity test date: 3 October 2019
- Purity: 99.927% w/w
- Physical state/appearance: Clear colorless liquid
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature in the dark
- Stability under test conditions: stable - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.35
- Temp.:
- 30 °C
- Remarks on result:
- other: no pH as the measure was done by HPLC
- Conclusions:
- The partition coefficient of 4,8-Dimethyl-2,5,7,10-tetraoxaundecane has been determined to be 22.6, log10 Pow 1.35.
- Executive summary:
The partition coefficient of 4,8-Dimethyl-2,5,7,10-tetraoxaundecane has been determined to be 22.6 (log10 Pow 1.35) using the HPLC method.
The result from the preliminary test indicated that the HPLC method was suitable for determination of partition coefficient for 4,8-Dimethyl-2,5,7,10-tetraoxaundecane.
Reference
Preliminary Estimate
The log10 Pow was calculated to be: 0.09
Definitive Test
Calibration
The retention times of the dead time and the retention times, capacity factors and log10 Pow values for the reference standards are shown in the following table:
Retention time (min) | ||||||
Standard | Injection 1 | Injection 2 | Mean | Capacity factor (k') | Log10 k' | Log10 Pow |
Thiourea (dead time) | 1.790 | 1.793 | 1.791 | - | - | - |
2 -Butanone | 2.564 | 2.567 | 2.565 | 0.432 | -0.364 | 0.3 |
Benzyl alcohol | 3.162 | 3.162 | 3.162 | 0.765 | -0.116 | 1.1 |
Benzonitrile | 4.206 | 4.207 | 4.206 | 1.35 | 0.130 | 1.6 |
Benzene | 7.036 | 7.043 | 7.039 | 2.93 | 0.467 | 2.1 |
Toluene | 10.991 | 10.988 | 10.989 | 5.13 | 0.710 | 2.7 |
Naphthalene | 16.765 | 16.768 | 16.767 | 8.36 | 0.922 | 3.6 |
Partition coefficient of sample
The retention time, capacity factor and log10 Pow values determined for the sample are shown in the following table:
Injection | Retention time (min) | Capacity factor (k') | Log10 k' | Log10 Pow |
1 | 3.866 | 1.16 | 6.36x10-2 | 1.36 |
2 | 3.863 | 1.16 | 6.30x10-2 | 1.35 |
Mean log10 Pow: 1.35
Partition coefficient: 22.6
Description of key information
A guideline study was performed using the HPLC method and the partition coefficient of 4,8-Dimethyl-2,5,7,10-tetraoxaundecane was determined to be 22.6.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.35
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.