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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Remarks:
- Read across data
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data was taken from secondary source
Data source
Reference
- Reference Type:
- other: Secondary source
- Title:
- SIDS Initial Assessment Report For SIAM 17
- Author:
- OECD-SIAM
- Year:
- 2 003
- Bibliographic source:
- OECD SIDS, SIAM, 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1976
- Principles of method if other than guideline:
- Acute skin irritation in vivo study was carried out for the given test chemical using rabbit species of both sex for determing the erythma and edema score
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-aminopropyltriethoxysilane
- EC Number:
- 213-048-4
- EC Name:
- 3-aminopropyltriethoxysilane
- Cas Number:
- 919-30-2
- Molecular formula:
- C9H23NO3Si
- IUPAC Name:
- 3-AMINOPROPYLTRIETHOXYSILANE
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Not specified
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dow Corning Corporation
- Age at study initiation:No data available
- Weight at study initiation: No data available
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum):No data available
- Acclimation period:No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%): No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light):No data available
IN-LIFE DATES: From: To:No data available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- Undilutated
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5ml
- Duration of treatment / exposure:
- 4 hrs
- Observation period:
- 14days
- Number of animals:
- 4 animals
- Details on study design:
- Not specified
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- all 4 animals
- Time point:
- other: 24 hrs and 72 hrs
- Score:
- 6.5
- Max. score:
- 11
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 4 animals
- Time point:
- other: 24 hrs and 72 hrs
- Score:
- 6.5
- Max. score:
- 11
- Reversibility:
- not specified
- Irritant / corrosive response data:
- Moderate to severe erythema with edema was observed on all animals after 24 hours exposure to the test material.After 72 hours, irritation became more pronounced on the abraded skin, leading to the formation of eschars
- Other effects:
- Not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- An unfailing study, like OECD 404, found that test material was corrosive when in contact for 4 h in rabbits, the erthyma and edema score was found to be 6.5
- Executive summary:
An unfailing study, like OECD "Acute Dermal Irritation/Corrosion" was performed for the RA chemical 3-aminopropyltriethoxysilane(CAS 919-30-2)using rabbits. The RA chemical was applied to all the animals at a dose of 0.5ml and observed for 72 hrs. After 24 hrs applications of a test sample to rabbit skin resulted in Moderate to severe erythema with edema observed on all animals. After 72 hours, irritation became more pronounced on the abraded skin, leading to the formation of eschars. The Primary Irritation Index was calculated to be 6.5. Hence the test material may classified as irritant to the skin of rabbits
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