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EC number: 443-050-2 | CAS number: 120903-40-4 PERFLUOROHEXANE NITRILE VINYL ETHER
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22nd June 2001 - 19th July 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2,2,3,3,4,4,5,5,6,6-decafluoro-6-trifluorovinyloxyhexanenitrile
- EC Number:
- 443-050-2
- EC Name:
- 2,2,3,3,4,4,5,5,6,6-decafluoro-6-trifluorovinyloxyhexanenitrile
- Cas Number:
- 120903-40-4
- Molecular formula:
- C8F13NO
- IUPAC Name:
- 2,2,3,3,4,4,5,5,6,6-decafluoro-6-[(1,2,2-trifluoroethenyl)oxy]hexanenitrile
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Perfluorohexane nitrile vinyl ether
- Lot/batch No.: Lot No. 3
- Expiration: 30th June, 2002
- Substance type: Pure active substance
- Physical state: clear colorless liquid
- Analytical purity: 93.8 Fl. % (GC)
- Storage condition of test material: In steel container, under inert gas (N2) at 2-8°C in refrigerator.
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Domestic sewage purification treatment plant, Frankfurt am Main-Kriftel, Germany
- Preparation of inoculum for exposure: After a settling period of approximately 30 minutes the supematant liquid phase was decanted and crude particles were removed by a sieve. After resuspension with mineral medium, settling down and decantation, the sludge was concentrated by centrifugation. Before resuspension, an aliquot of concentrated sludge was used for dry weight determination. 10 g concentrated sludge was then resuspended in 1 liter of mineral medium. Storage length and conditions were not specified. - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 250 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: standard mineral medium per OECD 301 guidelines.
- Test temperature: 21.1 - 22.8 °C
- pH: 7.4 - 7.5
- pH adjusted: no
- Suspended solids concentration: 30 mg/L
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 500-mL bottles in an incubation cabinet (22± 1°C), continuous stirring by magnetic induction
- Test solutions: Bottles contained suspended solids at 30 mg/L final concentration, test or reference substance suspended in mineral medium, and mineral medium to the indicated final volume (normally 250 mL).
- Number of culture flasks/concentration: two
- Measuring equipment: test done using Oxitop ® system (WTW GmbH, Germany) to measure reduction in pressure in bottles due to oxygen consumption. Bottles closed throughout test.
- Details of trap for CO2 and volatile organics if used: system uses a potassium hydroxide trap in bottle lid to trap evolved carbon dioxide.
SAMPLING
- Sampling frequency: daily
- Sampling method: electronic manometer in bottle lid, pressure read and BOD determined after data transfer.
CONTROL AND BLANK SYSTEM
- Inoculum blank: duplicate flasks. Activated sludge plus test medium to 250 mL total volume
- Abiotic sterile control: single flask. 100 mg 3,5-dichlorophenol (as biocide), 62.5 mg test substance, activated sludge plus test medium to 250 mL total volume.
- Toxicity control: 24.3 mg test substance, activated sludge, test medium to 97 mL total volume.
- Procedural control: 15 mg aniline, activated sludge, test medium to 250 mL total volume.
Reference substance
- Reference substance:
- aniline
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- Oxygen demand was less in test bottles than inoculum control throughout test except test bottles 1 and 2 on days 1-3 (see Table 2).
BOD5 / COD results
- Results with reference substance:
- Reference substance aniline was 67% degraded by day 7 and 94% degraded on day 28 (see Table 2)
Any other information on results incl. tables
Table 1. Cumulative biochemical oxygen demand by test bottle (mg/L)
Test day |
Test bottle 1¹ |
Test bottle 2¹ |
Blank bottle 1 |
Blank bottle 2 |
Reference bottle² |
Abiotic control¹ |
Toxicity control³ |
1 |
1.4 |
0 |
4.2 |
1.4 |
0 |
0 |
5.6 |
2 |
4.2 |
4.2 |
8.5 |
4.2 |
0 |
0 |
11.3 |
3 |
7.0 |
4.2 |
9.9 |
7.0 |
1.4 |
0 |
5.6 |
4 |
9.9 |
5.6 |
9.9 |
8.5 |
8.5 |
0 |
28.2 |
5 |
8.5 |
8.5 |
12.7 |
9.9 |
83.1 |
0 |
95.8 |
6 |
12.7 |
8.5 |
14.1 |
11.3 |
91.6 |
0 |
101 |
7 |
14.1 |
9.9 |
15.5 |
12.7 |
110 |
0 |
113 |
8 |
12.7 |
11.3 |
16.9 |
14.1 |
120 |
0 |
130 |
9 |
14.1 |
12.7 |
18.3 |
15.5 |
125 |
0 |
135 |
10 |
16.9 |
14.1 |
16.9 |
14.1 |
128 |
0 |
130 |
11 |
15.5 |
12.7 |
19.7 |
16.9 |
132 |
0 |
141 |
12 |
15.5 |
15.5 |
19.7 |
16.9 |
135 |
1.4 |
146 |
13 |
18.3 |
15.5 |
19.7 |
16.9 |
137 |
0 |
146 |
14 |
16.9 |
15.5 |
21.1 |
18.3 |
139 |
1.4 |
146 |
15 |
18.3 |
15.5 |
21.1 |
16.9 |
141 |
1.4 |
152 |
18 |
19.7 |
18.3 |
22.5 |
18.3 |
144 |
1.4 |
152 |
19 |
18.3 |
18.3 |
22.5 |
18.3 |
145 |
1.4 |
158 |
20 |
18.3 |
18.3 |
24.0 |
19.7 |
147 |
1.4 |
158 |
21 |
18.3 |
18.3 |
24.0 |
19.7 |
147 |
1.4 |
158 |
22 | 21.1 | 18.3 | 24.0 | 18.3 | 147 | 1.4 | 152 |
25 | 21.1 | 19.7 | 22.5 | 18.3 | 149 | 1.4 | 152 |
26 | 19.7 | 19.7 | 25.4 | 19.7 | 154 | 2.8 | 163 |
27 | 21.1 | 19.7 | 25.4 | 19.7 | 155 | 2.8 | 158 |
28 | 21.1 | 22.5 | 22.5 | 18.3 | 156 | 0 | 152 |
1. Perfluorohexane nitrile vinyl ether at 250 mg/L (ThOD[ammonium], 145 mg/L). Abiotic control was additionally treated with 250 mg/L 3,5 dichlorophenol as biocid
2, Reference substance aniline at 60 mg/L (ThOD[ammonium], 144 mg/L)
3, Toxicity control contained Perfluorohexane nitrile vinyl ether at 250 mg/L and aniline at 60 mg/L, ThOD [ammonium], 289 mg/L total
Table 2. Biodegradation (% BOD/ThOD)
Time |
Test substance bottle 1 |
Test substance bottle 2 |
Reference substance |
Toxicity control |
1 |
-1 |
-2 |
-2 |
1 |
2 |
-2 |
-2 |
-4 |
-2 |
3 |
-1 |
-3 |
-5 |
-1 |
4 |
0 |
-2 |
0 |
7 |
5 |
-2 |
-2 |
50 |
29 |
6 |
0 |
-3 |
55 |
31 |
7 |
0 |
-3 |
67 |
34 |
8 |
-2 |
-3 |
73 |
40 |
9 |
-2 |
-3 |
75 |
41 |
10 |
1 |
-1 |
78 |
40 |
11 |
-2 |
-4 |
79 |
43 |
12 |
-2 |
-2 |
81 |
44 |
13 |
0 |
-2 |
83 |
44 |
14 |
-2 |
-3 |
83 |
44 |
15 |
0 |
-2 |
85 |
46 |
18 |
0 |
-1 |
86 |
46 |
19 |
-1 |
-1 |
87 |
48 |
20 |
-2 |
-2 |
87 |
47 |
21 |
-2 |
-2 |
87 |
47 |
22 |
0 |
-2 |
88 |
45 |
25 |
0 |
0 |
90 |
46 |
26 | -2 | -2 | 91 | 48 |
27 | -1 | -2 | 92 | 47 |
28 | 0 | 1 | 94 | 46 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- Validity criteria: Difference in test sub biodeg <20%, ref sub passed by day 14 (67% degraded by 7d), >35% biodeg in tox control (46% degraded by 28d), O2 demand in blank 20-30 mg/L (18.3 and 22.5 mg/L).
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- MV5CN is not readily biodegradable (OECD 301 F), and does not inhibit biodegradation.
- Executive summary:
Biodegradability of MV5CN was assessed in a OECD301F assay. Aniline was used as reference substance and in a toxicity control. The reference bottle achieved a passing level (67% BOD/ThOD[ammonium]) by day 7. No biodegradation was observed in duplicate test substance bottles. In the toxicity control, total oxygen demand was 46% after 28 days as compared to 92% oxygen demand in the reference substance bottle. MV5CN is not readily biodegradable, but does not inhibit biodegradation.
The test was conducted according to internationally accepted guidelines in accord with GLP criteria. It is considered reliable without restrictions and is acceptable for Risk Assessment, Classification & Labeling, and PBT Analysis.
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