Registration Dossier
Registration Dossier
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EC number: 617-251-2 | CAS number: 816431-72-8
Endpoint summary
Administrative data
Description of key information
Oral (Rat, GLP, OECD TG 423): LD50 > 2000 mg/kg [Schuengel, 2006]
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Mar - May 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 2001
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Route of administration:
- oral: gavage
- Vehicle:
- other: tap water with 2% Cremophor EL
- Doses:
- 2000 mg/kg body weight (bw)
- No. of animals per sex per dose:
- 3 female rats
- Control animals:
- no
- Details on study design:
- dosing of 3 additional animals with the same dose (2000 mg/kg)
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Gross pathology:
- no findings
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- the test item is of low acute oral toxicity.
- Executive summary:
The single oral administration of the test substance (Amidchlorid, CAS 816431-72-8) to female rats at a dose of 2000 mg/kg was tolerated without any mortality. No compound-related clinical signs were observed and there were no macroscopic pathological signs.
The LD50 acute oral toxicity of Amidchlorid (CAS 816431-72-8) in rats is therefore above 2000 mg/kg body weight.
Reference
A dose of 2000 mg/kg body weight was tolerated by female rats without mortalities,
clinical signs, effects on weight gain and gross pathological findings.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 2 000 mg/kg bw
- Quality of whole database:
- Klimisch score 1
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the study results a classification according to Regulation (EC) No. 1272/2008 (CLP) is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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