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EC number: 600-588-4 | CAS number: 104617-50-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October to November 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- N-(2-Methyl-4,5,6,7-tetrahydro-benzothiazol-6-yl)-acetamide hydrobromide
- EC Number:
- 600-588-4
- Cas Number:
- 104617-50-7
- Molecular formula:
- C9 H13 O N3 S x HBr
- IUPAC Name:
- N-(2-Methyl-4,5,6,7-tetrahydro-benzothiazol-6-yl)-acetamide hydrobromide
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
2 m and 2 f rabbits, Chbb:HM (Himalayan)
Weight: 2.1 - 2.7 kg
Age : 19 - 22 weeks
Acclimatization period: > 2 weeks
Supplier: Dr. Karl Thomae GmbH
ENVIRONMENTAL CONDITIONS
Individual accommodation in stainless steel wire cages, with a floor area of 3878 cm2.
Temperature: 22 +3 -1°C;
Relative humidity: 55 (50 - 65) %.
A cycle of 12:12 hrs. light: darkness was maintained.
Feed
Standardized pelleted feed 9980 (Altromin, Lage). Certificates of analysis relating to nutritional content and presence of contaminants of the batches used are kept in the archives of the Laboratory Animal Services Unit of Boehringer lngelheim .
Drinking water
Filtered, demineralized water of drinking quality was adjusted to pH 2.6 ±
0.2 with hydrochloric acid and was freely available to the animals.
Duration and date of the study
1 week
26.10.1994 - 02.11.1994
Test system
- Type of coverage:
- other: occlusive right side | semi-occlusive on the left side
- Preparation of test site:
- clipped
- Vehicle:
- physiological saline
- Controls:
- yes
- Amount / concentration applied:
- 0.3 g test article moistened with 0.5 ml physiological saline, or 0.5 ml physiological saline2) as control, was applied once to a 3 x 3 cm square area of shaved skin.
- Duration of treatment / exposure:
- 4 hrs
- Observation period:
- The state of health and behaviour of the animals were checked twice daily and abnormalities were recorded in writing. On Saturdays, Sundays, and holidays, the clinical observations were carried out only once daily.
- Number of animals:
- 2 male rabbits
2 female rabbits - Details on study design:
- The technique employed in this study was based on that described by Draize (1959)1) and on the OECD Guidelines for the Testing of Chemicals, 404, 17.07.1992, as well with reference to EC Regulation no. L383A, dated 29.12.1992.
The animals were prepared by shaving the dorsal region with electric clippers 15 - 24 hours before topical application. Only animals with healthy, smooth, and intact skin were employed in the study.
0.3 g test article moistened with 0.5 ml physiological saline, or 0.5 ml physiological saline2) as control, was applied once to a 3 x 3 cm square area of shaved skin.
The test article or physiological saline was applied and covered with the aid of gauze bandage patches (3 x 3 cm), on the right side occlusively3) (airtight) and on the left side semi-occlusively4) (with plaster), and enclosed in a protective bandage5)_ After 4 hours the gauze patches were removed.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1/24/72h and 1 week
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1/24/72h and 1 week
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 1/24/72h and 1 week
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 1/24/72h and 1 week
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 1/24/72h and 1 week
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 1/24/72h and 1 week
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- other: 1/24/72h and 1 week
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- other: 1/24/72h and 1 week
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified according to CLP
- Conclusions:
- SND 919 CL2 Y Precursor 1 = SND 919 Thiazol was evaluated as having no irritant potential.
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