Registration Dossier
Registration Dossier
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EC number: 607-988-8 | CAS number: 2668-75-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 1981
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 17-Acetoxy-1,4,6-pregnatriene-3,20-dione
- EC Number:
- 607-988-8
- Cas Number:
- 2668-75-9
- Molecular formula:
- C23 H28 O4
- IUPAC Name:
- 17-Acetoxy-1,4,6-pregnatriene-3,20-dione
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
No animal died in the course of the study. A single i.g. application of the limit-dose was tolerated without compound-related findings. The body weight gain on days 7 and 14 was within the normal range for rats of this age and strain, with the exception of female animals showing a slight decrease in body weight gain on Day 7. No compound-related clinical findings could be detected at the end of the study on Day 14. Autopsy also revealed no compound-related findings.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- the test item is of low acute oral toxicity
- Executive summary:
A single oral administration of the test substance (ZK 5560) to male and female rats at the limit-dose (2000 mg/kg) was tolerated without mortalities. No compound-related clinical signs or effects on body weight gain were observed and also autopsy revealed no compound-related findings.
The acute oral toxicity of the substance in rats is therefore above 2000 mg/kg body weight.
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