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EC number: 200-823-7 | CAS number: 74-94-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In a study from Tsan et al. the clinical toxicity of dimethylamine borane poisoning of a worker, exposed acutely with this substance without immediately decontamination, was reported. Symptoms including dizziness, nausea, limb numbness, slurred speech, irritable mood, and ataxia were noted. A nerve conduction study revealed polyneuropathy with motor-predominant axonal degeneration. Further cases of DMAB exposure were reported by Tsan et al., where 4 workers were exposed with DMAB, but decontaminated immediately by drinking water or take a shower. In these cases, minor intoxication without any residual neurologic sequelae occurred.
A further poisoning incident was reported by Hung et al. In this report the axonal neuropathy after acute DMAB exposure was studied. The study indicates that acute exposure to Dimethylamine borane (DMAB) may induce axonal polyneuropathy. This is in line with the findings of Tsan et al.
In another study, a worker acutely exposed with DMAB was studied on long-term neurotoxic effects. The study showed that DMAB intoxication lead to long-lasting CNS toxicity on the cognitive dysfunction, parkinsonism and an impaired metabolic activity of the brain.
Based on these studies it can be concluded that acute DMAB exposure without immediate decontamination leads primarily to neurotoxicity and polyneuropathy with motor-predominant axonal degeneration and cause long-lasting CNS toxicity.
Additional information
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