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Diss Factsheets
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EC number: 473-690-8 | CAS number: 738602-93-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: Assessment based on available information
- Adequacy of study:
- key study
- Study period:
- May 2021
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Objective of study:
- absorption
- distribution
- excretion
- metabolism
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- according to (EC) No 1907/2006, Annex VIII, Column I, Section 8.8.1, an assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from the relevant available information is done
- GLP compliance:
- no
- Specific details on test material used for the study:
- the reported composition and structural information of the constituents is taken into account only. No physical test material was used.
- Type:
- excretion
- Results:
- Giving the high water solubility and the substance consists of glucosides and saccharides, Excretion via urine is rather likely for any substance not metabolised.
Excretion by inhalation is rather unlikely. - Type:
- metabolism
- Results:
- The substance is likely to be fully metabolised, for details, see field "any other information on results incl. tables"
- Type:
- distribution
- Results:
- The substance is very hydrophilic and Protein binding is unlikely relevant. For details, see field "any other information on results incl. tables".
Based on the very low partition coefficient, the high water solubility and the assumed readiness for meta - Type:
- absorption
- Results:
- dermal and inhalative absorption are assumed to be low. The substance should be absorbed orally to a high amount. For details, see field "any other information on results incl. tables"
- Conclusions:
- Based on available information, the Absorption, Distribution, Metabolism and Excretion of the substance are assessed.
Reference
Absorption:
Some components (ca. 10 %) of the UVCB substance are small enough to be absorbed through the skin (Molecular weight below 500 g/mol). The major part of the components has a molecular weight above 500 mg/ml However, the calculated log Pow and the measured log Pow are clearly out of range to be readily absorbed. Based on above considerations the substance is unlikely to be absorbed through the skin in relevant amounts (none of the following apply: molecular weight < 500 g/Mol, -1 < log POW < 4, see EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRETORATE-GENERAL: Guidance Document on Dermal Absorpiton Sanco/222/2000 rev. 7 19 March 2004).
For exposure assessments a value of 10 % of absorption after dermal exposure may be appropriate.
Uptake by inhalation after evaporation is unlikely, the substance is a liquid at room temperature and has a very low vapour pressure.
For exposure assessments a default value of 10 % of absorption via inhalation may be appropriate.
The absorption after oral ingestion cannot be calculated due to lack of data; by default absorption of 100 % may be appropriate, until specific data will be available.
Distribution:
The substance is very hydrophilic and Protein binding is unlikely relevant. The high water solubility may lead to a low distribution volume. Therefore distribution to specific organs is depending mainly on blood flow. Crossing of membrane barriers like the Blood/Brain barrier seems unlikely giving the molecular weight and the high hydrophilicity of the substance.
However, as the substance constitutes of polyols and glucosides, specific transfer enzymes may enhance the cellular uptake of constituents of the substance.
Metabolism and Excretion:
The substance does contain glucosides and saccharides, with the alcohol part of the glucosides being an sugar alcohol. All these constituents are naturally present substances which can be formed and metabolized by the human body by specialised enzymes. Therefore the classically relevant Phase I and Phase II-Metabolism does not apply to the substance.
The components of the substance are likely to enter the general sugar metabolism and being metabolized to Carbon dioxide and Water in the end. As the different oligomers are connected by a 1,4-glycosidic bond, the first step may be the cleavage of this bond to result finally Glucose and Glycitol.
Giving the high water solubility and the substance consists of glucosides and saccharides, Excretion via urine is rather likely for any substance not metabolised.
Excretion by inhalation is rather unlikely.
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 10
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.