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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reason / purpose for cross-reference:
- exposure-related information
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 7 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 7.37 mg/L
- Duration:
- 7 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 7.45 mg/L
- Duration:
- 7 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 8.17 mg/L
- Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- Details on hydrolysis and appearance of transformation product(s):
- - Formation and decline of each transformation product during test: mono-, di-, and triester were detected; the tri-esters were rapidly degraded to di-esters, which sequentially degrade to the mono-esters
- Pathways for transformation: ester cleavage - pH:
- 4
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0.01 h-1
- DT50:
- 27.3 d
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0.01 h-1
- DT50:
- 72.3 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0.01 h-1
- DT50:
- 47.8 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.69 a-1
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.01 h-1
- DT50:
- 17 d
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.01 h-1
- DT50:
- 11.3 d
- Type:
- (pseudo-)first order (= half-life)
Reference
Description of key information
Half-life:
> 1 year at a pH of 4 and 25 °C
17 days at a pH of 7 and 25 °C
11.3 days at a pH of 9 and 25 °C
(OECD TG 111 / EU-method C.7, preliminary test; RL1; GLP; read-across: partially unsaturated TEA-Esterquat)
Key value for chemical safety assessment
Additional information
No experimental data on the hydrolysis of the target substance Esterification products of triglycerides C18 unsaturated with triethanolamine, dimethyl sulfate quaternized are available. However, a hydrolysis study is available for the closely related source substance partially unsaturated TEA-Esterquat. A justification for read-across is attached to Iuclid section 13.
The hydrolysis of partially unsaturated TEA-EQ as a function of pH was investigated in a study conducted according to OECD Guideline 111 and EU-method C.7. (Preliminary test; main test not conducted due to the pronounced biodegradability of the test substance).
The following results were obtained:
Hydrolysis of partially unsaturated TEA-EQ at 50°C
pH
|
Temperature (°C)
|
Rate constant
|
t1/2
|
4 |
50 |
0.00106 1/h |
27.3 d |
7 |
50 |
0.00958 1/h |
72.3 h |
9 |
50 |
0.01449 1/h |
47.8 h |
Hydrolysis of partially unsaturated TEA-EQ at 25°C
pH
|
Temperature (°C)
|
Rate constant
|
t1/2
|
4 |
25* |
0.693 1/a |
>1 a* |
7 |
25 |
0.00169 1/h |
17.0 d |
9 |
25 |
0.00256 1/h |
11.3 d |
* default assumption acc. to guideline
At pH 4 and 50°C, the degradation of the main component of partially unsaturated TEA-EQ was less than 10% over a period of 120 h. The corresponding half-life at 25°C is therefore assumed to be above one year (default assumption acc. to guidelines). In contrast, at pH 7 and 9 and 50°C, more than 10% of the test item were hydrolysed within 120 h. Based on the results half-lives of 17 (pH 7) and 11.3 d (pH 9) were deduced from the reaction rate constants at 25°C. Di- and mono-ester were detected as degradation products
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