Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 641-487-5 | CAS number: 40150-92-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- occlusive testing; no single animal data provided; Relevant details on materials and methods (e.g. test concentrations) not provided
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-[4-(2-methylpropyl)phenyl]ethan-1-ol
- Cas Number:
- 40150-92-3
- Molecular formula:
- C12 H18 O
- IUPAC Name:
- 1-[4-(2-methylpropyl)phenyl]ethan-1-ol
- Details on test material:
- No further data provided
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml of liquid test material (not specified, if applied undiluted)
- Duration of treatment / exposure:
- 4h
- Observation period:
- 7 days
- Number of animals:
- 6
- Details on study design:
- - test sample applied to about 6 square centimeters of clipped skin,
- site covered with a gauze patch and adhesive tape, T
- after patch removal skin was washed with warm water to remove residual test material.
- Evaluation of skin condition using Draize scoring system, approx. 1h and 1, 2, 3, 4, 5, 6 and 7 d after patch removal
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Remarks:
- maximum mean dermal irritation soore
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 2.8
- Max. score:
- 8
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- Slight to well-defined erythema with edema was reported for all 6 animals. This would translate to skin related effects with a score of 1 to 2.
Irritation was absent from all animals 7 days after treatment.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
