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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
Test material
- Test material form:
- solid: flakes
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Technically not Feasible.
- Executive summary:
Analytical monitoring of the test tem in the aqueous puffer solutions used for tha hydrolysis studie according to the guideline OECD 111 is not possible due to the low water solubility of the test item and high analytical detection limit / low sensitivity of the analytical method.
No test item could be detected in aqueous samples of aquatoxicity studies (Noack ID: 180706CM / DAI18315 and SPO18315) when test samples were prepared as water accommodated fractions (WAF). Only approximately 0.1 to 1 mg test item/L can be detected though a LC-MS/MS system, known as analytical device enabling the implementation of analytical methods with highest sensitivity. Furthermore, no stock solutions of the test item, for application into an aqueous phases, in concentrations adequate for analytical monitoring can be prepared. Only 50 mg test item/L can be dissolved in toluene under heating (Noack ID: 180706CM / CAD18315N) and this solution is unsuitable for aqueous spiking.
In combination, these facts impair the accurate deduction of the study endpoints required by the guideline OECD111, as a reliable and sensitive quantitation of the test item in the aqueous buffer solutions during the experiments is mandatory for their calculation. The low water solubility, the low sensitivity of the analytical method and the the lack of suitable solvents for the praparation of stock solutions for spiking of aqueous solutions, led to the assessmet, that a hydrolysis study according to OECD guideline 111 is technically not feasible.
The experimental determination of the hydrolysis as a function of pH of
LICOCARE RBW 300 FL TP
according to the OECD guideline OECD 111 isTechnically not Feasible.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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