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EC number: 421-090-1 | CAS number: 131298-44-7 Isodecyl benzoate
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07/26/1994 - 10/12/1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report equivalent or similar to OECD 474
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OTS 798.5395 (In Vivo Mammalian Cytogenics Tests: Erythrocyte Micronucleus Assay)
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- -
- EC Number:
- 421-090-1
- EC Name:
- -
- Cas Number:
- 131298-44-7
- Molecular formula:
- C17H26O2
- IUPAC Name:
- undecyl benzoate
- Reference substance name:
- Benzoic acid, C9-11, C10-rich branched alkyl esters
- IUPAC Name:
- Benzoic acid, C9-11, C10-rich branched alkyl esters
- Details on test material:
- - Name of test material (as cited in study report): Isodecyl Benzoate
- Physical state: clear pale yellow liquid
- Analytical purity: 98%
- Lot/batch No.: C5-8
- Expiration date of the lot/batch: 15 May 1996
- Storage condition of test material: Room temperature
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River U.K. Limited, Margate, Kent, England
- Age at study initiation: approximately 35 days old on despatch
- Assigned to test groups randomly: yes
- Housing: each group was kept, with the sexes separated, in plastic disposable cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 - 25 °C
- Humidity (%): 50 - 64 %
- Air changes (per hr): 20 per hour
- Photoperiod (hrs dark / hrs light): 12 hours light/dark
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- - Vehicle(s)/solvent(s) used: 1% Methylcellulose
- Lot/batch no. (if required): T32398 - Duration of treatment / exposure:
- All animals in all groups were dosed with the standard volume of 20 mL/kg bodyweight or 1280 mg/kg bodyweight. Test substance and negative control were dosed by intraperitoneal injection. Mitomycin C, the positive control, was dosed orally by intragastric gavage at 12 mg/kg bodyweight. The animals in the the postive control group were deprived of diet overnight prior to and two hours after dosing.
- Frequency of treatment:
- Single acute intraperitoneal administration of test substance
- Post exposure period:
- 72 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1280 mg/kg
Basis:
other: bodyweight
- No. of animals per sex per dose:
- 15 animals per sex (male/female) 30 animals total per dose (Vehicle/Isodecyl Benzoate)
5 animals per sex (male/female) 10 animals total per dose (Mitomycin C) - Control animals:
- yes, concurrent vehicle
- Positive control(s):
- mitomycin C;
- Route of administration: orally, intragastric gavage
- Doses / concentrations: 12 mg/kg bodyweight
Examinations
- Tissues and cell types examined:
- Bone marrow smears were obtained from test substance and negative control groups at 24, 48 and 72 hours after dosing. Bone marrow smears were obtained form the positive control group at 24 hours after dosing.
- Evaluation criteria:
- Smears from each animal were examined for the presence of micronuclei in 1000 polychromatic erythrocytes. The ratio of polychromatic to normochromatic erythrocytes was assessed by examination of at least 1000 erythrocytes from each animal.
A positive response is normally indicated by a substantial, statistically significant increase (P < 0.01) in the incidence of micronucleated polychromatic erythrocytes compared to the incidence for the concurrent vehicle control group for at least one of the sampling times: individual and/or group mean values should exceed the laboratory historical control range. A negative result is indicated where individual and group mean incidences of micronucleated polychromatic erythrocytes for animals treated with the test substance are not significantly greater (P>0.01) than incidences for the concurrent control group and where these values fall within the historical control range. An equivocal response is obtained when the resutls cannot be adequately classified using the criteria for a positive or negative response.
Bone marrow cell toxicity (or depression) is normally indicated by a substantial, statistically significant decrease (P<0.01) in the ratio of polychromatic to normochromatic erythrocytes. This decrease would normally be evident at the 48 and 72 hour sampling points, a decrease a tthe 24 hour time point is not necessarily expected because of the relatively long transition time of erythroid cells. A very large decrease in this ratio would be indicaive of a cytostatic or cytotoxic effect.
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Isodecyl benzoate did not cause any substantial increase in the incidence of micronucleated polychromatic erythrocytes, Isodecyl benzoate did not show any evidence of causing chromosome damage when administered intraperitoneal in this in vitro test. Bone marrow cell toxicity/depression is indicated by the statistically significant decrease in the ratio of polychromatic to normochromatic erythrocytes obtained for animals treated with Isodecyl benzoate.
- Executive summary:
Isodecyl benzoate, when adminsitered by intraperitoneal injection at 1280 mg/kg bodyweight, did not cause a substantial increase in the incidence of micronucleated polychromatic erythroytes. Isodecyl benzoate did not show evidence of causing chromosome damage in this in vivo test. Isodecyl benzoate produced bone marrow cell toxicity/depression as indicated by a statistically significant decrease in the ratio of polychromatic to normochromatic erythrocytes obtained for treated animals.
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