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EC number: 406-250-0 | CAS number: 72619-32-0 HALOXYFOP R-(+)-ME HERBICIDAL CHEMICAL
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- XRD 535 METHYL
Lot #: RN 88-7R
Purity: 98% - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0.085 µg/mL XRD-535 acid and 0.055 µg/mL test substance
- Sample storage conditions before analysis: Deep frozen - Vehicle:
- yes
- Remarks:
- Tween 80 (polyoxyethylene sorbitan monooleate)
- Details on test solutions:
- The test substance was suspended in the test medium by sonicating for 30 minutes at a concentration of 100 mg/100 ml (stock suspension) using Tween 80 (0.10 g/100 ml) as solubilizing agent. Thereafter, series of sequential dilutions with the test medium were prepared to obtain the final test concentrations of the test article. The highest concentration of Tween 80 was 0.01%. Along with the test substance, control samples with and without Tween 80 were tested.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Strain/clone: Daphnia magna
- Age at study initiation: Less than 24 hrs
- Source: Laboratories of RCC
- Feeding during test : No feeding - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 20 ± 2°C
- pH:
- Initial: 8.3
Final: 8.2 - Dissolved oxygen:
- Initial: 8.5 mg/L
Final: 8.4 mg/L - Nominal and measured concentrations:
- Nominal: 0 (control with tween 80), 0 (control without tween 80), 0.78, 1.56, 3.13, 6.25, 12.5, 25, 50, 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Beaker
- Material, size, headspace, fill volume: 50 mL beakers containing 20 mL test medium
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- No. of vessels per vehicle control (replicates): 2
TEST MEDIUM
- CaCl2.2H2O: 294 mg/L
- MgSO4.7H2O: 123 mg/L
- NaHCO3: 65 mg/L
- KCl: 5.8 mg/L
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 6.12 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Immobility
- Remarks on result:
- other: 95% CL: 4.10-12.41 mg/L
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 30.66 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Immobility
- Remarks on result:
- other: 95% CL: 13.26-78.38 mg/L
- Details on results:
- - Mortality of control: No mortality was observed within 48 hours for the untreated control. The mortality of Tween 80-treated samples was 0% after 24 and 48 hours of exposure.
- Results with reference substance (positive control):
- 48 h EC50: 1.3 mg/L (1.1-1.8 mg/L)
24 h EC50: 1.7 mg/L (1.4-2.0 mg/L) - Validity criteria fulfilled:
- yes
- Conclusions:
- 48 h EC50 (D. magna): 6.12 mg/L
24 h EC50 (D. magna): 30.66 mg/L - Executive summary:
The test substance was tested for its acute toxicity to Daphnia magna under static conditions for 48 hours. The tests were performed according to OECD guideline 202 and EU method C.2. Concentrations tested were 0 (control), 0.78, 1.56, 3.13, 6.25, 12.5, 25, 50 and 100 mg/L. The low, medium and high concentrations were sampled for acid and ester content. Analysis showed partial hydrolysis of the ester to the corresponding acid.
The EC0 after 24 and 48 hours was determined to be 1.95 and 1.09 mg/L, respectively. The 24 and 48 hours EC50 of the test substance based on initial nominal concentrations were calculated to be 30.66 and 6.12 mg/L, respectively. It is concluded that the test substance showed a slight toxicity to daphnids when exposed for 24 hours. After 48 hours, the toxicity increased to the moderate level.
The immobilization rate of the control animals was 0% after 48 hours. The tests were validated by testing potassium dichromate. The EC50 values determined for potassium dichromate after 24 and 48 hours were 1.7 and 1.3 mg/L, respectively.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 72-3 (Estuarine/Marine Fish, Mollusk, or Shrimp Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Haloxyfop-methyl
Lot #: AGR 229637
Purity: 99.5% - Analytical monitoring:
- yes
- Vehicle:
- yes
- Remarks:
- dimethyl formamide (DMF)
- Test organisms (species):
- other: Crassostrea virginica (Eastern oyster)
- Test type:
- flow-through
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 23.6-24.4°C
- pH:
- 7.8-8.0
- Dissolved oxygen:
- 6.3 mg/L (91% saturation) and 7.1 mg/L (100% saturation)
- Salinity:
- 31-32%
- Nominal and measured concentrations:
- Nominal: 0 (dilution water control), 0 (solvent control), 0.065, 0.108, 0.180, 0.300, 0.500 mg/L
- Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: new shell growth
- Remarks on result:
- other: 95% CL: 0.29-0.35 mg/L
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.098 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: new shell growth
Referenceopen allclose all
Description of key information
48-hour EC50 (Daphnia magna): 6.12 mg/L; OECD 202, EU Method C.2; Reliability = 1
96-hour EC50 (Crassostrea virginica): 0.32 mg/L; EPA 72 -3; Reliability = 1
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 6.12 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 0.32 mg/L
Additional information
Acute aquatic invertebrate tests were conducted in one freshwater species and one marine species. The 48-h EC50 value in fresh water species, Daphnia magna was 6.12 mg/L and 96 -h EC50 in marine water species, Crassostrea virginica was 0.32 mg/L.
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