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EC number: 210-719-3 | CAS number: 622-08-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: screening test, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- GLP compliance:
- no
- Key result
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks on result:
- other: The substance was predicted as "Possible Readily Biodegradable"
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Based on the results of "Ready Biodegradability model (IRFMN) 1.0.9" substance is considered "Possible readily biodegradable".
- Executive summary:
The model classified the chemical compound as "Possible Readily Biodegradable", considering that the target compound fall within the applicability domain of the model, we can consider the prediction reliable. Furthermore, the similarity of the the structural analogues is very high (ranging from 0.85 to 0.92). All analogues were experimentally found to be "ready biodegradable" and were also good predicted by the model.
The fingerprint for the "Possible RB" no. 15 (ethane-1,2-diol; SMARTS: OCCO) was found within the molecular structure.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Guideline:
- other: REACH Guidance on QSARs R.6
- GLP compliance:
- no
- Specific details on test material used for the study:
- SMILE: C1=CC=C(C=C1)COCCO
- Key result
- Parameter:
- other:
- Remarks on result:
- other:
- Remarks:
- Biowin1 (Linear Model Prediction): Biodegrades Fast; Biowin2 (Non-Linear Model Prediction): Biodegrades Fast; Biowin3 (Ultimate Biodegradation Timeframe): Weeks; Biowin4 (Primary Biodegradation Timeframe): Days; Biowin5 (MITI Linear ModelPrediction): Readily Degradable Biowin6 (MITI Non-Linear Model Prediction): Readily Degradable Biowin7 (Anaerobic Model Prediction): Does Not Biodegrade Fast Ready Biodegradability Prediction: YES
- Key result
- Parameter:
- other: The chemical compound was predicted As READILY BIODEGRADABLE
- Validity criteria fulfilled:
- not applicable
- Interpretation of results:
- readily biodegradable
- Conclusions:
- On the basis of the results obtained by BIOWIN Models, the 2-benzyloxyethanol is predicted as Readily biodegradable
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 310 (Ready Biodegradability - CO2 in Sealed Vessels (Headspace Test)
- Version / remarks:
- 2014
- Deviations:
- no
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, predominantly domestic (adaptation not specified)
- Details on inoculum:
- For the preparation of the inoculum a sample of aerobic sludge has been selected by the mixed treatment plant of urban (about 66%) and industrial (about 34%) liquid sewage situated at San Rocco - Monza (MB), Italia. The plant of treatment is managed by “BRIANZACQUE SRL (Monza)”.
In the laboratory, the sampled muds have been mixed and let settle, keeping them in aerobic conditions for 4 days. The mud samples, before their use, have been analysed to check its ability to form colony units. Then it has been centrifuged, washed and analyzed to quantify the suspended solids concentration for the inoculum preparation. The inoculum was prepared in order to have a concentration of suspended solid of about 4 mg/L. - Duration of test (contact time):
- ca. 28 d
- Initial conc.:
- ca. 31.37 mg/L
- Based on:
- TOC
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- Medium preparation:
Solution A
Formula Concentration (g/L)
Anhydrous potassium dihydrogenphosphate KH2PO4 8.50
Anhydrous dipotassium hydrogenphosphate K2HPO4 21.75
Disodium hydrogenphosphate dihydrate Na2HPO4.2H2O 33.40
Ammonium chloride NH4 CI 0.50
pH = 7.51
Solution B
Formula Concentration (g/L)
Calcium chloride dihydrate CaCl2 2H2O 36.40
Solution C
Formula Concentration (g/L)
Magnesium sulfate heptahydrate MgSO4 7H2O 22.50
Solution D
Formula Concentration (g/L)
Iron chloride (III) hexahydrate FeCl3 6H2O 0.25
All solutions have been made with deionized water (MilliQ Millipore).
Then for each litre of medium 10 mL of Solution A have been transferred into a 1000 mL volumetric flask and diluted with 800 mL of deionised water; 1 mL of Solution B, 1 mL of Solution C and 1 mL of
Solution D have been added and the solution has been diluted to volume with deionised water.
For higher volumes the medium has been prepared according to the same proportion. The preparation of the solutions has been reported in an internal logbook - Reference substance:
- other: 1-octanol
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- ca. 75
- Sampling time:
- 28 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- On the basis of results obtained, interpreted in accordance to OECD 310:2014, the test item “ID 47955 - BENZYL GLYCOL CAS-NO.622-08-2 EC-NO.210-719-3” is considered readily biodegradable in aerobic conditions
- Executive summary:
On the test item the analysis of inorganic carbon for the evaluation in an aqueous medium of the aerobic biodegradability has been performed following screening method described in OECD 310: 2014.
For this purpose the amount of developed inorganic carbon has been measured and reported in comparison to the blank.
The test has been done using the test item with a fixed concentration of organic carbon.
Samples have been kept at the temperature of 20 ± 1 °C for the whole period of the test (28 days).
On the basis of results obtained, interpreted in accordance to OECD 310:2014, the test item is considered readily biodegradable in aerobic conditions.
Referenceopen allclose all
Compound SMILES: OCCOCc1ccccc1
Experimental value: -
Predicted RB activity: Possible Readily Biodegradable
No. alerts for non Ready Biodegradability (RB): 0
No. alerts for possible non RB: 0
No. alerts for RB: 0
No. alerts for possible RB: 1
Structural alerts: Possible RB alert no. 15 (ethane-1,2-diol)
Reliability: the predicted compound is into the Applicability Domain of
the model
SMILES : c1ccc(cc1)COCCO
CHEM :
MOL FOR: C9 H12 O2
MOL WT : 152.19
--------------------------- BIOWIN v4.10 Results
----------------------------
Biowin1 (Linear Model Prediction) : Biodegrades Fast
Biowin2 (Non-Linear Model Prediction): Biodegrades Fast
Biowin3 (Ultimate Biodegradation Timeframe): Weeks
Biowin4 (Primary Biodegradation Timeframe): Days
Biowin5 (MITI Linear Model Prediction) : Readily Degradable
Biowin6 (MITI Non-Linear Model Prediction): Readily Degradable
Biowin7 (Anaerobic Model Prediction): Does Not Biodegrade Fast
Ready Biodegradability Prediction: YES
Biowin1 |
||||
TYPE |
NUM |
Biowin1 FRAGMENT DESCRIPTION |
COEFF |
VALUE |
Frag |
1 |
Aliphatic alcohol [-OH] |
0.1587 |
0.1587 |
Frag |
1 |
Aliphatic ether [C-O-C] |
-0.3474 |
-0.3474 |
Frag |
1 |
Unsubstituted phenyl group (C6H5-) |
0.1281 |
0.1281 |
MolWt |
* |
Molecular Weight Parameter |
|
-0.0725 |
Const |
* |
Equation Constant |
|
0.7475 |
RESULT |
Biowin1 (Linear Biodeg Probability) |
0.6145 |
Biowin2 |
||||
TYPE |
NUM |
Biowin2 FRAGMENT DESCRIPTION |
COEFF |
VALUE |
Frag |
1 |
Aliphatic alcohol [-OH] |
1.1178 |
1.1178 |
Frag |
1 |
Aliphatic ether [C-O-C] |
-3.4294 |
-3.4294 |
Frag |
1 |
Unsubstituted phenyl group (C6H5-) |
1.7991 |
1.7991 |
MolWt |
* |
Molecular Weight Parameter |
-2.1612 |
|
RESULT |
Biowin2 (Non-Linear Biodeg Probability) |
0.583 |
A Probability Greater Than or Equal to 0.5 indicates --> Biodegrades Fast
A Probability Less Than 0.5 indicates --> Does NOT Biodegrade Fast
Biowin3 |
||||
TYPE |
NUM |
Biowin3 FRAGMENT DESCRIPTION |
COEFF |
VALUE |
Frag |
1 |
Aliphatic alcohol [-OH] |
0.16 |
0.16 |
Frag |
1 |
Aliphatic ether [C-O-C] |
-0.0087 |
-0.0087 |
Frag |
1 |
Unsubstituted phenyl group (C6H5-) |
0.022 |
0.022 |
MolWt |
* |
Molecular Weight Parameter |
|
-0.3363 |
Const |
* |
Equation Constant |
|
3.1992 |
RESULT |
Biowin3 (Survey Model - Ultimate Biodeg) |
3.0362 |
Biowin4 |
||||
TYPE |
NUM |
Biowin4 FRAGMENT DESCRIPTION |
COEFF |
VALUE |
Frag |
1 |
Aliphatic alcohol [-OH] |
0.1294 |
0.1294 |
Frag |
1 |
Aliphatic ether [C-O-C] |
-0.0097 |
-0.0097 |
Frag |
1 |
Unsubstituted phenyl group (C6H5-) |
0.0049 |
0.0049 |
MolWt |
* |
Molecular Weight Parameter |
-0.2196 |
|
Const |
* |
Equation Constant |
3.8477 |
|
RESULT |
Biowin4 (Survey Model - Primary Biodeg) |
3.7528 |
Result Classification: 5.00 -> hours 4.00 -> days 3.00 -> weeks
(Primary & Ultimate) 2.00 -> months 1.00 -> longer
Biowin5 |
||||
TYPE |
NUM |
Biowin5 FRAGMENT DESCRIPTION |
COEFF |
VALUE |
Frag |
1 |
Aliphatic alcohol [-OH] |
0.1611 |
0.1611 |
Frag |
1 |
Aliphatic ether [C-O-C] |
0.0015 |
0.0015 |
Frag |
1 |
Aromatic-CH2 |
-0.0557 |
-0.0557 |
Frag |
5 |
Aromatic-H |
0.0082 |
0.0411 |
Frag |
2 |
-CH2- [linear] |
0.0494 |
0.0988 |
MolWt |
* |
Molecular Weight Parameter |
|
-0.4528 |
Const |
* |
Equation Constant |
|
0.7121 |
RESULT |
Biowin5 (MITI Linear Biodeg Probability |
0.5062 |
Biowin6 |
||||
TYPE |
NUM |
Biowin6 FRAGMENT DESCRIPTION |
COEFF |
VALUE |
Frag |
1 |
Aliphatic alcohol [-OH] |
1.0041 |
1.0041 |
Frag |
1 |
Aliphatic ether [C-O-C] |
-0.1071 |
-0.1071 |
Frag |
1 |
Aromatic-CH2 |
-0.1246 |
-0.1246 |
Frag |
5 |
Aromatic-H |
0.1201 |
0.6007 |
Frag |
2 |
-CH2- [linear] |
0.4295 |
0.859 |
MolWt |
* |
Molecular Weight Parameter |
|
-4.3937 |
RESULT |
Biowin6 (MITI Non-Linear Biodeg Probability) |
0.59 |
A Probability Greater Than or Equal to 0.5 indicates --> Readily
Degradable
A Probability Less Than 0.5 indicates --> NOT Readily Degradable
Biowin7 |
||||
TYPE |
NUM |
Biowin7 FRAGMENT DESCRIPTION |
COEFF |
VALUE |
Frag |
1 |
Aliphatic alcohol [-OH] |
0.1328 |
0.1328 |
Frag |
1 |
Aliphatic ether [C-O-C] |
-0.2573 |
-0.2573 |
Frag |
1 |
Unsubstituted phenyl group (C6H5-) |
0.2182 |
0.2182 |
Frag |
1 |
Aromatic-CH2 |
-0.0073 |
-0.0073 |
Frag |
5 |
Aromatic-H |
-0.0954 |
-0.4772 |
Frag |
2 |
-CH2- [linear] |
0.026 |
0.052 |
Const |
* |
Equation Constant |
|
0.8361 |
RESULT |
Biowin7 (Anaerobic Linear Biodeg Prob) |
0.4973 |
A Probability Greater Than or Equal to 0.5 indicates --> Biodegrades Fast
A Probability Less Than 0.5 indicates --> Does NOT Biodegrade Fast
Ready Biodegradability Prediction: (YES or NO)
----------------------------------------------
Criteria for the YES or NO prediction: If the Biowin3 (ultimate survey
model) result is "weeks" or faster (i.e. "days", "days to weeks", or
"weeks" AND the Biowin5 (MITI linear model) probability is >= 0.5, then
the prediction is YES (readily biodegradable). If this condition is not
satisfied, the prediction is NO (not readily biodegradable). This method
is based on application of Bayesian analysis to ready biodegradation data
(see Help). Biowin5 and 6 also predict ready biodegradability, but for
degradation in the OECD301C test only; using data from the Chemicals
Evaluation and Research Institute Japan (CERIJ) database.
Description of key information
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
The substance is readly biodegrable according to
- OECD 310
- VEGA-Hub (Ready Biodegradability model version 1.0.9)US EPA’s EPISuite estimation program v4.11 (models BIOWIN1, BIOWIN2, BIOWIN3, BIOWIN4, BIOWIN5, BIOWIN6 and BIOWIN7)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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