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Reaction mass of lithium sodium hydrogen 4-amino-6-({5-[(5-chloro-2,6-difluoropyrimidin-4-yl)amino]-2-sulfonatophenyl}diazenyl)-5-hydroxy-3-[(4-{[2-(sulfonatooxy)ethyl]sulfonyl}phenyl)diazenyl]naphthalene-2,7-disulfonate and lithium sodium hydrogen 4-amino-6-({5-[(5-chloro-2,6-difluoropyrimidin-4-yl)amino]-2-sulfonatophenyl}diazenyl)-5-hydroxy-3-{[4-(vinylsulfonyl)phenyl]diazenyl}naphthalene-2,7-disulfonate
EC number: 941-533-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12-07-2001 to 26-07-2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.8 (Toxicity for Earthworms: Artificial Soil Test)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- TEST ORGANISM
- Common name: Earthworm
- Source: ECT GmbH
- Age at test initiation (mean and range, SD): approximately 5 months (adult with clitellum)
- Weight at test initiation (mean and range, SD): 300-600 mg (wet weight)
ACCLIMATION
- Acclimation period: 48 h
- Acclimation conditions (same as test or not): same - Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- no
- Total exposure duration:
- 14 d
- Test temperature:
- 18-22°C
- pH:
- 6.1-6.5
- Moisture:
- 32-38%
- Details on test conditions:
- TEST SYSTEM
- Test container (material, size): 2 L glass beaker (covered with perforated plastic film at the start of test to reduce evaporation)
- Amount of soil or substrate: 500 g dry weight
- No. of organisms per container (treatment): ten
- No. of replicates per treatment group: four
- No. of replicates per control: four
SOURCE AND PROPERTIES OF SUBSTRATE (if soil)
- Geographic location: artificial soil
- Composition (if artificial substrate): 10% dry weight sphagnum peat (pH of 5.5-6.0, no visible plant remains, finely ground and dried), 20% kaolin clay and 70% industrial sand
- Maximum water holding capacity (in % dry weigtht): 35-42
OTHER TEST CONDITIONS
- Photoperiod: continuous
- Light intensity: 400-800 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality
TEST CONCENTRATIONS
- Spacing factor for test concentrations: two - Nominal and measured concentrations:
- Nominal: 62.5, 125, 250, 500 and 1000 mg/kg soil dw
- Reference substance (positive control):
- no
- Duration:
- 14 d
- Dose descriptor:
- LC0
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Key result
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 14 d
- Dose descriptor:
- LC100
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- No adverse effects were observed in any of the test worms at any concentration.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the nominal 14 d LC0, LC50 and LC100 of the test substance to the earthworms were determined to be >1000 mg/kg soil dw.
- Executive summary:
A study was conducted to determine the toxicity of the test substance to earthworms according to OECD Guideline 207 and EU Method C.8, in compliance with GLP. Forty earthworms per concentration in 500 g artificial soil were exposed to nominal concentrations of 0, 62.5, 125, 250, 500 and 1000 mg/kg soil dw for 14 d. Temperature, pH and moisture were recorded at test start and end. No adverse effects or mortality were observed in any of the test concentrations. Under the study conditions, the nominal 14 d LC0, LC50 and LC100 of the test substance to the earthworms were determined to be >1000 mg/kg soil dw (Ensenbach, 2001).
Reference
Description of key information
The nominal 14 d LC0, LC50 and LC100 of the test substance to the earthworms were determined to be >1000 mg/kg soil dw.
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 1 000 mg/kg soil dw
Additional information
A study was conducted to determine the toxicity of the test substance to earthworms according to OECD Guideline 207 and EU Method C.8, in compliance with GLP. Forty earthworms per concentration in 500 g artificial soil were exposed to nominal concentrations of 0, 62.5, 125, 250, 500 and 1000 mg/kg soil dw for 14 d. Temperature, pH and moisture were recorded at test start and end. No adverse effects or mortality were observed in any of the test concentrations. Under the study conditions, the nominal 14 d LC0, LC50 and LC100 of the test substance to the earthworms were determined to be >1000 mg/kg soil dw (Ensenbach, 2001).
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