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EC number: 609-099-0 | CAS number: 352303-67-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31st May 2018 - 2nd July 2018
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: MEP, P.R. China, the Guideline for the Testing of Chemicals, Degradation and Accumulation (the Second Edition), No. 301F "Manometric Respirometry Test. (2013.9)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (2-fluoro-3-methoxyphenyl)boronic acid
- EC Number:
- 609-099-0
- Cas Number:
- 352303-67-4
- Molecular formula:
- FC6H3(OCH3)B(OH)2
- IUPAC Name:
- (2-fluoro-3-methoxyphenyl)boronic acid
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Lot number: 18051400
Appearance: Off-white powder
Storage: Room temperature 15-25 C
Purity: 100.2%
Study design
- Inoculum or test system:
- sewage, predominantly domestic (adaptation not specified)
- Details on inoculum:
- A fresh sample of activated sludge was collected from a sewage treatment plant as recommended by the OECD Guidelines for the Testing of Chemicals. A fresh sample of activated sludge was collected from the aeration tank of Shenyang North Sewage Treatment Plant 4 days before the test exposure began. It is a well-functioning treatment plant receiving predominantly domestic sewage.
- Duration of test (contact time):
- 28 d
Results and discussion
% Degradation
- Key result
- Parameter:
- other: degradation percentage was obtained from BOD/ThOD as per guidelines described in OECD 301 F
- Value:
- 14.3
- Sampling time:
- 28 d
- Remarks on result:
- other:
- Details on results:
- Based on the results, the percentage biodegradation within 28 days did not exceed the pass level of 60% ThOD. The test item did not meet the criteria for ready biodegradability under the described test conditions.
BOD5 / COD results
- Results with reference substance:
- The biodegradation of the reference substance (Sodium benzoate) attained 64.2% after Day 5, 95.3% after Day 14 and 93.6% after Day 28
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- All validity criteria were fulfilled as per described test guidelines.
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The test item did not meet the criteria for ready biodegradability under the described test conditions.
- Executive summary:
The ready biodegradability test of FMPBA was conducted with unacclimatised sewage micro-organisms by measuring oxygen consumption over the 28-day test period.
The biodegradation of test item after 28 days averaged 14.3% (2 replicates). The test item did not exhibit a percentage biodegradation exceeding the pass level of 60% within the 28-day period.
The biodegradation of the reference substance (Sodium benzoate) attained 64.2% after Day 5, 95.3% after Day 14 and 93.6% after Day 28.
In the Toxicity Control (TC) test mixture, 41.3% degradation occurred within 14 days and the value exceeded 25% based on total ThOD, which indicated that the test item can be assumed to be not inhibitory under the conditions of this test.
In the Abiotic Sterile Control (ASC) Test Vessel, 17.2% degradation occurred after 28 days.Based on the results, the percentage biodegradation within 28 days did not exceed the pass level of 60% ThOD. The test item did not meet the criteria for 'ready biodegradability' under the described test conditions.
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