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EC number: 254-290-0 | CAS number: 39098-97-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- December 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test:
1-hr inhalation exposure
- Short description of test conditions: rats are exposed for 1 hour to 2 mg/L air and then observed during 14 days
- Parameters analysed / observed: clinical signs, mortality, body weight, autopsie - GLP compliance:
- no
- Test type:
- fixed concentration procedure
Test material
- Reference substance name:
- 2-thienylacetyl chloride
- EC Number:
- 254-290-0
- EC Name:
- 2-thienylacetyl chloride
- Cas Number:
- 39098-97-0
- Molecular formula:
- C6H5ClOS
- IUPAC Name:
- 2-thienylacetyl chloride
- Test material form:
- liquid
- Details on test material:
- - Density: 1.29
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Females (if applicable) nulliparous and non-pregnant: no data
- Age at study initiation: no data
- Weight at study initiation: 202.8g for males and 190.2g for females on D0 (mean value)
- Fasting period before study: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes: around 10/hours
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
A parallelepipedic glass vessel, 100L in volume, is continuously crossed by the atmosphere overloaded with the product. These vapors are obtained by creating a vaporization of the product inside a glass column: this column is fed, on the one hand, with compressed air at a known and adjustable flow rate and, on the other hand, with the liquid substance also arriving at a determined rate by means of a syringe infuser (Perfusor Braun).
This 100L vessel is crossed by the overloaded atmosphere with a flow rate of approximately 1 m3 per hour. A ventilator located inside the vessel homogenises continuously the atmosphere. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 1 h
- Concentrations:
- 2.05 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighing D0, 2, 4, 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.05 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- >= 2.05 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- no mortality
- Clinical signs:
- other: during the exposure: attempted escape, hyperactivity, closing of the palpebral fissure, sneezing, trembling, loose breathing movements. after the exposure: tachycardia (D0-1), hyperactivity (D0-4), then normal behavior.
- Body weight:
- no effect
- Gross pathology:
- whitish mottling and numerous red spots in the lungs in several animals.
gastric mucous irritation in one female.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- In this study in rats the 1-hr LC0 is 2.05 mg/L (no mortality is observed).
- Executive summary:
In an acute inhalation toxicity study, groups of Sprague-Dawley rats (5/sex) were exposed by inhalation route to 2-thienylacetyl chloride for 1 hour (whole body) at concentration of 2.05 mg/L. Animals then were observed for 14 days.
LC0 Combined = 2.05 mg/L (no mortality occurred)
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