Registration Dossier
Registration Dossier
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EC number: 209-247-0 | CAS number: 563-41-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- not specified
- Remarks:
- Draft report
- Adequacy of study:
- weight of evidence
- Study period:
- NA
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- No other data available
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- This document is a preliminary draft. It has not been released formally by the office of Toxic substances, Office of the Pesticides ans Toxic substances, U.S. Environmental Protection Agency, and should not at thsi stage be construed to represent Agency policy. It is being circulated for comments on its technical merit and policy implications.
- GLP compliance:
- no
- Test type:
- other: A superficial review of available data on acute toxicity
- Limit test:
- no
Test material
- Reference substance name:
- Semicarbazide hydrochloride
- EC Number:
- 209-247-0
- EC Name:
- Semicarbazide hydrochloride
- Cas Number:
- 563-41-7
- Molecular formula:
- CH5N3O.ClH
- IUPAC Name:
- semicarbazide hydrochloride
Constituent 1
- Specific details on test material used for the study:
- NA
Test animals
- Species:
- other: Mouse, Rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- NA
Administration / exposure
- Route of administration:
- other: Oral, Intraperitoneal and Subcutaneous
- Vehicle:
- not specified
- Details on oral exposure:
- Not Specified
- Doses:
- Not Specified
- No. of animals per sex per dose:
- Not Specified
- Control animals:
- not specified
- Details on study design:
- Not Specified
- Statistics:
- Not Specified
Results and discussion
- Preliminary study:
- Not Specified
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Remarks:
- Oral / Mouse
- Effect level:
- >= 176 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: NA
- Sex:
- not specified
- Dose descriptor:
- LDLo
- Remarks:
- Oral / Rat
- Effect level:
- >= 10 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: NA
- Sex:
- not specified
- Dose descriptor:
- LD50
- Remarks:
- Intraperitoneal / Mouse
- Effect level:
- >= 123 mL/kg bw
- Based on:
- not specified
- Remarks on result:
- other: NA
- Sex:
- not specified
- Dose descriptor:
- LD50
- Remarks:
- Intraperitoneal / Rat
- Effect level:
- >= 140 mg/kg bw
- Sex:
- not specified
- Dose descriptor:
- LD50
- Remarks:
- Subcutaneous / Mouse
- Effect level:
- >= 105 mg/kg bw
- Remarks on result:
- other: NA
- Sex:
- not specified
- Dose descriptor:
- LD50
- Remarks:
- Subcutaneous / Rat
- Effect level:
- >= 173 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: NA
- Sex:
- not specified
- Dose descriptor:
- LD50
- Remarks:
- Intravenous / Mouse
- Effect level:
- >= 126 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: NA
- Mortality:
- Not Specified
- Clinical signs:
- other: Not Specified
- Gross pathology:
- Not Specified
- Other findings:
- Not Specified
Any other information on results incl. tables
Not Specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- These old data showed that SCH may be very toxic when administered acutely to rats and mice via oral, intraperitoneal, subcutaneous and intravenous routes.
All the value obtained for the LD50 are around 100mg/kg, the test item is therefore classify as Category 3 based on the GHS criteria. - Executive summary:
These old data showed that SCH may be very toxic when administered acutely to rats and mice via oral, intraperitoneal, subcutaneous and intravenous routes.
All the value obtained for the LD50 are around 100mg/kg, the test item is therefore classify as Category 3 based on the GHS criteria.
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