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EC number: 684-597-9 | CAS number: 1072005-10-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- EG 92/69 C 1
- Principles of method if other than guideline:
- Highest and only measured concentration: 39 mg/L
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- No details available.
- Vehicle:
- no
- Details on test solutions:
- The test item was prepared with deionised water (1g/L) and shaked for 18h. Thereafter the solution was filtrated and the DOC value determined.
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zebra fish
- Strain: not available
- Source: West Aquarium, Bad Lauterberg
- Length at study initiation: 3 cm ± 0.5 cm
ACCLIMATION
- Acclimation period: 14 days
- Acclimation conditions: same as test conditions
- Type and amount of food during acclimation: TetraMin, 1% of the body weight
- Health during acclimation: mortality ≤ 5 %
- Treatment: 3 times a week Malachite green
FEEDING DURING TEST
No feeding during test - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 12 °dH
- Test temperature:
- 19 - 20 °C
- pH:
- 7.8 - 8.5
- Dissolved oxygen:
- 86 - 108% Saturation
- Nominal and measured concentrations:
- Measured concentration: 39 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: aquarium
- Material, fill volume: glass, 10L
- Aeration: continuous
- Renewal rate of test solution: daily change
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Biomass loading rate: 0.27 g / Fisch
TEST MEDIUM / WATER PARAMETERS
- Source of dilution water: Drinking water of Gelsenwasser AG
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16h light/ 8h dark
- Light intensity: no details available
EFFECT PARAMETERS MEASURED: Lethality (every 24 h) - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 39 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 39 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 39 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: no
- Other biological observations: no
- Mortality of control: no
- Other adverse effects control: no
- Abnormal responses: no
- Any observations that might cause a difference between measured and nominal values: no - Sublethal observations / clinical signs:
Table 1: Analytical results
Concentration (mg/L)
Mean values of new solutions
0h
24h (old)
24h (new)
48h
72h
4.1
5.1
4.7
68*
81*
39
*Oversaturated solution, generation of droplets on surface
- Validity criteria fulfilled:
- yes
- Conclusions:
- In the fish acute test a EC50 value > 39 mg/L was determined.
- Executive summary:
The toxicity of the test item to fish (Danio rerio) was determined according to the principles of OECD 203. The aim of the study was the determination of NOEC, LOEC, EC10- , EC20- and EC50-values of lethality over a period of 96 hours. The study was conducted under semi-static conditions with renewal of the test solution after 24 h. A stock solution of 1 g/L was prepared with deionised water. The concentration was calculated from the new solutions to be 39 mg/L. Two replicates were tested for the test item concentration and for the control. The environmental conditions were within the acceptable limits. No lethality was observed. The following results were determined: EC50 >39 mg/L, NOEC = 39 mg/L, LOEC > 39 mg/L.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- EG 92/69 C 1
- Principles of method if other than guideline:
- Highest and only measured concentration: 14 mg/L
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- The analytical determination of the stability of the test item was tested separately. Concentrations of 0.5, 1.2 and 2.4 mg/L were analyzed after 24, 48 and 72 h. The recovery rate was >80%, therefor nominal values were used for the test. During the test no concentrations were measured.
- Vehicle:
- no
- Details on test solutions:
- The test item was prepared with deionised water (1g/L) and shaked for 18h. Thereafter the solution was filtrated and the DOC value determined.
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Common carp
- Strain: not available
- Source: Bio International B.V ., Someren NL
- Length at study initiation: 2 - 4 cm
ACCLIMATION
- Acclimation period: 14 days
- Acclimation conditions: same as test conditions
- Type and amount of food during acclimation: TetraMin, 1% of the body weight
- Health during acclimation: mortality ≤ 5 %
FEEDING DURING TEST
No feeding during test - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 13 °dH
- Test temperature:
- 20.3 - 21.9 °C
- pH:
- 7.6 - 8.1
- Dissolved oxygen:
- 70 - 98% Saturation
- Nominal and measured concentrations:
- Measured concentration: 14 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: aquarium
- Material, fill volume: glass, 10L
- Aeration: continuous
- Renewal rate of test solution: daily change
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Biomass loading rate: 0.85 g / Fisch
TEST MEDIUM / WATER PARAMETERS
- Source of dilution water: Drinking water of Gelsenwasser AG
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16h light/ 8h dark
- Light intensity: no details available
EFFECT PARAMETERS MEASURED: Lethality (every 24 h) - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 14 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 14 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 14 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: no
- Other biological observations: no
- Mortality of control: no
- Other adverse effects control: no
- Abnormal responses: no
- Any observations that might cause a difference between measured and nominal values: no - Sublethal observations / clinical signs:
Table 1: Analytical results
Concentration (mg/L)
Mean values of new solutions
0h
24h
48h
72h
19.1
19.2
14.4
2.9
14
Partial oversaturated solution, generation of droplets on surface
- Validity criteria fulfilled:
- yes
- Conclusions:
- In the fish acute test a EC50 value > 14 mg/L was determined.
- Executive summary:
The toxicity of the test item to fish (Cyprinus carpio) was determined according to the principles of OECD 203. The aim of the study was the determination of NOEC, LOEC, EC10- , EC20- and EC50-values of lethality over a period of 96 hours. The study was conducted under semi-static conditions with renewal of the test solution after 24 h. A stock solution of 1 g/L was prepared with deionised water. The concentration was calculated from the new solutions to be 14 mg/L. Two replicates were tested for the test item concentration and for the control. The environmental conditions were within the acceptable limits. No lethality was observed. The following results were determined: EC50 >14 mg/L, NOEC = 14 mg/L, LOEC > 14 mg/L.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to chapter 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 39 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 39 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 39 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to chapter 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 14 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 14 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 14 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Referenceopen allclose all
Description of key information
No data on the test item is available. With the read-across substances the following results were obtained:
CAS 68583-51-7: EC50 > 39 mg/L, NOEC = 39 mg/L
CAS 853947-59-8: EC50 > 14 mg/L, NOEC = 14 mg/L
Key value for chemical safety assessment
Additional information
No data on the test item is available. With the read-across substances the following results were obtained:
The toxicity of the read-across substance CAS 68583-51-7 to fish (Danio rerio) was determined according to the principles of OECD 203. The aim of the study was the determination of NOEC, LOEC, EC10- , EC20- and EC50-values of lethality over a period of 96 hours. The study was conducted under semi-static conditions with renewal of the test solution after 24 h. A stock solution of 1 g/L was prepared with deionised water. The concentration was calculated from the new solutions to be 39 mg/L. Two replicates were tested for the test item concentration and for the control. The environmental conditions were within the acceptable limits. No lethality was observed. The following results were determined: EC50 >39 mg/L, NOEC = 39 mg/L, LOEC > 39 mg/L.
The toxicity of the read-across substance CAS 853947-59-8 to fish (Cyprinus carpio) was determined according to the principles of OECD 203. The aim of the study was the determination of NOEC, LOEC, EC10- , EC20- and EC50-values of lethality over a period of 96 hours. The study was conducted under semi-static conditions with renewal of the test solution after 24 h. A stock solution of 1 g/L was prepared with deionised water. The concentration was calculated from the new solutions to be 14 mg/L. Two replicates were tested for the test item concentration and for the control. The environmental conditions were within the acceptable limits. No lethality was observed. The following results were determined: EC50 >14 mg/L, NOEC = 14 mg/L, LOEC > 14 mg/L.
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