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EC number: 238-056-5 | CAS number: 14205-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Two oral tox. studies were performed. Only one study can be used as key study. Based on the higher number of animals of both sexes used within the key study, this study seems to have a higher reliability. The other study is a dose range finder study with two females and only used as a supporting study.
In the key study the acute oral toxicity of the test item was determined in male and female rats after single administration of seven concentrations with an application volume of 20 mL/kg
via stomach tube with an observation period of 14 d. The acute oral LD50 was 1760 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single administration of seven concentrations with an application volume of 20 ml/kg to fasted rats (5 males and 5 females) via stomach tube with an observation period of 14 days
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Fasted (no food 16 h before and 4 h after application) - Route of administration:
- oral: gavage
- Vehicle:
- other: Lutrol (PEG 400)
- Doses:
- 1300, 1500, 1800, 1900, 2000, 2500 and 3100 mg/kg with an application volume of 20 ml/kg
- No. of animals per sex per dose:
- 10 ( 5 males and 5 females)
- Control animals:
- no
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 760 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 610 - <= 1 910
- Mortality:
- All deaths occurred on the first day after administration.
- Clinical signs:
- other: No symptoms at dose 1300 mg/kg. All animals at dose 1500 mg/kg and above symptomatic (e.g. reduced general condition, cyanosis, ventral or lateral position, narcosis, dyspnea). Clinical signs occurred after 5 to 10 min after administration, on day 3 all
- Gross pathology:
- Bleedings in the mucous membrane of the stomach.
- Other findings:
- No abnormal findings seen at final necropsy
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral LD50 was 1760 mg/kg.
- Executive summary:
The acute oral toxicity of methyl 3 -aminocrotonate was determined in fasted male and female rats after single administration of seven concentrations with an application volume of 20 ml/kg via stomach tube with an observation period of 14 d. The acute oral LD50 was 1760 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 760 mg/kg bw
- Quality of whole database:
- reliable
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 October 1999 - 23 March 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- Feb. 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Version / remarks:
- July 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Version / remarks:
- August 1998
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- White crystalline solid stored in the dark at ambient temperature.
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Five male and 5 female (nulliparous and non-pregnant) young adult rats of the Sprague-Dawley strain were used. They were approximately 8 weeks old and
weighed 164-230 g on arrival. They were supplied by Harlan UK and arrived at lnveresk Research on 20 October 1999. The animals were allowed to acclimatise for 8 days prior to commencement of the study. The animals were housed individually in suspended polypropylene cages (dimensions 42 x 27 x 20 em), with stainless steel grid tops and bottoms, suspended over absorbent paper lined trays.
Each cage was supplied with a stainless steel food hopper and polypropylene water bottle with cap and stainless steel nozzle.
Mean environmental maximum and minimum temperatures were 22°C and 19°C, and the mean relative humidity was 48%. A 12 h light/dark cycle was in
operation (light hours 0700-1900 h) with a minimum of 15 air changes per hour. - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 10 (5 male and 5 females)
- Control animals:
- no
- Details on study design:
- The test material was administered topically in a single 24 h application, under occlusion as follows:
One day prior to test material application the dorsal area of the trunk of each rat was clipped free of hair (approximately 7 cm x 8 cm),
taking care to avoid abrading the skin. On the following day, the appropriate quantity of finely ground test material,
which was calculated to be approximately 41 mg.cm-2 was applied onto the water moistened dorsal skin and spread uniformly over the trunk
(approximately 4% of the total body surface). The test material was then covered b,t a water moistened gauze patch (5 cm x 6 cm), secured with
Micropore (3M Medical-Surgical Division, USA) semi-occlusive tape, and a strip of non-irritating occlusive tape (Sleek, Smith and Nephew Medical
Limited, USA) wound round the trunk. The dose was calculated based on the weight of the animal on the day of dosing.
After a contact period of 24 h the patches were removed and the test sites delineated. The skin was then wiped with sterile distilled water. - Statistics:
- No formal statistical analysis was conducted.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no premature decedents during the study.
- Clinical signs:
- other: On the day of dosing, clinical signs were limited to red discharge from the eyes and nose. Other clinical signs noted were dry flaky skin and/or scabbing from Day 6 up to Day 15. A wet perigenital area was noted in 2 of the female animals on Day 2 only.
- Gross pathology:
- Dry, red, scabbing on the dorsal surface was noted in 2 female animals.
- Other findings:
- No other abnormalities were noted in the remaining animals.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the study, the Median Dermal Lethal Dose (LD50) of LZ937 in Sprague-Dawley rats is estimated to be greater than 2000 mg/kg bw.
- Executive summary:
A acute dermal toxicity study was performed in year 1999/2000 according to OECD Guideline 402 and GLP. One group of 5 male and 5 female rats was exposed to a 24 h dermal
application of 2000 mg/kg b.w.. The test material was applied topically to the water moistened dorsal trunk of each animal under water moistened occlusive patches.
The animals were observed daily for viability and signs of reaction to treatment for up to 14 days after dosing. There were no premature decedents or major clinical signs noted during the
study. Body weight performance was generally considered to have been satisfactory, and there were no major findings noted at necropsy.
Under the conditions of the study, the Median Dermal Lethal Dose (LD50) of LZ937 in Sprague-Dawley rats is estimated to be greater than 2000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- reliable
Additional information
Justification for classification or non-classification
Based on the GHS criteria, the substance has to be classified as Acute Tox. 4; H302.
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