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EC number: 214-022-5 | CAS number: 1073-05-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- OECD Guideline for Testing of Chemicals - Section 4: Health Effects, 423, 2001
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 1,3,2-dioxathiane 2,2-dioxide
- EC Number:
- 214-022-5
- EC Name:
- 1,3,2-dioxathiane 2,2-dioxide
- Cas Number:
- 1073-05-8
- Molecular formula:
- C3H6O4S
- IUPAC Name:
- 1,3,2λ⁶-dioxathiane-2,2-dione
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material: 1,3,2-dioxathiane 2,2-dioxide
- IUPAC name: 1,3,2-Dioxathiane 2,2-dioxide
- Molecular formula: C3H6O4S
- Molecular weight: 138.14 g/mol
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 1,3,2-dioxathiane 2,2-dioxide
- IUPAC name: 1,3,2-Dioxathiane 2,2-dioxide
- Molecular formula: C3H6O4S
- Molecular weight: 138.14 g/mol
- Substance type: Organic
- Physical state: Solid
Test animals
- Species:
- rat
- Strain:
- other: Rattus norvegicus
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Test animals
Nine rats female (Rattus norvegicus) young adult lineage Wistar, nulliparous and non-pregnant were used after inspection and acclimation to the laboratory conditions for 5 days.
1st Treatment
Age: 9 weeks
Weight between: 176.30 g to 189.94 g
Acquired from: ANILAB – Animais de Laboratório Criação e Comércio Ltda
Batch: 021/18
2nd Treatment
Age: 9 weeks
Weight between: 173.29 g to 200.55 g
Acquired from: ANILAB – Animais de Laboratório Criação e Comércio Ltda
Batch: 021/18
3rd Treatment
Age: 9 weeks
Weight between: 182.91 g to 197.20 g
Acquired from: ANILAB – Animais de Laboratório Criação e Comércio Ltda
Batch: 022/18
Environmental Conditions
The animals’ rooms were maintained in controlled and monitored environmental conditions during the entire study conduct for: temperature, humidity and room ventilation. Temperature and humidity data were noted in book of records.
Temperature: Min: 19.0 ºC; Max: 22.8 ºC
Humidity: Min: 41 %; Max: 69%
Light cycles: 12 hours light / 12 hours dark
Room Ventilation: 10 to 15 air changes per hour
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 300 and 2000 mg Kg-1 of body weight
- No. of animals per sex per dose:
- 3 animals
- Control animals:
- not specified
- Details on study design:
- This acute oral toxicity study in rats (Rattus norvegicus) was carried out in order to evaluate the possible toxic effects of the test substance 1,3,2-Dioxathiane, 2,2-dioxide administered by the oral route. Nine females, divided in groups of three animals, were tested in three steps at the dose levels of 300 and 2000 mg kg-1 of body weight. The test substance was applied diluted using purified water as vehicle. The volume administered to each animal was calculated according to the body weight determined on the day of treatment. After dosing by gavage, the animals were observed during 14 days to evaluate deaths, and behavioral and clinical alterations.
Results and discussion
- Preliminary study:
- Not applicable.
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 mg/kg bw
- Based on:
- test mat.
- Mortality:
- when administered by oral route in female rats, cause deaths, for every step taken at the dose levels of 2000 mg kg-1 of body weight. 3 (all) females in the high dose group died (1 at 5.4 hours and 2 on day 1)
- Clinical signs:
- other: The animals were examined for death and systemic signs of toxicity with special attention during the first 4 hours after dosing and during 14 days after the test substance application. Observations included but not limited at: changes in skin and fur, eye
- Gross pathology:
- No test-article related changes were reported.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral LD50 value of the test substance 1,3,2-Dioxathiane, 2,2-dioxide was estimated to be greater than 300 mg/kg of body weight for female rats.
- Executive summary:
In this guideline (OECD 423) comparable study, the test substance 1,3,2-Dioxathiane, 2,2-dioxide, when administered by oral route in female rats, cause deaths, for every step taken at the dose levels of 2000 mg kg-1 of body weight. In clinical examinations, the tested animals did not show systemic signs of toxicity. In macroscopic evaluations no alterations were observed during the necropsies. Based on the flow chart with the starting dose of 300 mg kg-1 of body weight, the test substance was classified as category 4, according to the GHS (Globally Harmonized Classification System for Chemical Substances and Mixtures). The oral LD50 value of test substance 1,3,2-Dioxathiane, 2,2-dioxide, for female rats, was estimated to be 300 mg kg-1 of body weight.
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