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EC number: 700-251-2 | CAS number: 72684-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-12-12 to 2009-01-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Dose level selection changed to limit test at 5000 mg/kg
- GLP compliance:
- yes
- Test type:
- up-and-down procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 4-hydroxy-3,5-dimethoxybenzonitrile
- Cas Number:
- 72684-95-8
- IUPAC Name:
- 4-hydroxy-3,5-dimethoxybenzonitrile
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- - Composition of test material, percentage of components: syringonitrile 99.8%
- Expiration date of the lot/batch: May 2010
-Physical description: pale yellow powder
-solubility: soluble in water
-stability: test substance was expected to be stable for the duration of the testing.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Received from Ace Animals Inc, Boyertown, PA, on Nov. 25 and Dec. 30, 2008
- Age at study initiation: young adult (9-11 weeks)
-Weight at study initiation: 178-220 grams
- Housing: singly housed in suspended stainless steel cage
- Diet (e.g. ad libitum): pelleted Purina Rodent Chow
- Water (e.g. ad libitum): filtered tap water was supplied ad libitum by an automatic water dispensing system.
- Acclimation period:10-20 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-21°C
- Humidity (%): 15-60%
- Photoperiod (hrs dark / hrs light):12 hr light/dark cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- - Concentration in vehicle: Test substance was administered as a 35% w/w mixture in a 0.5% solution of carboxymethyl cellulose in distilled water using a stainless steel ball-tipped gavage needle attached to an appropriate syringe.
- Doses:
- Limit test at 5000 mg/kg
- No. of animals per sex per dose:
- 3 female rats
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observed for gross toxicity, mortality and behavioural changes during the first several hours after dosing and at least once daily thereafter for 14 days. Weights recorded pre-dosing, day 7 and day 14.
- Necropsy of survivors performed: yes -- tissues and organs of thoracic and abdominal cavities were examined.
Results and discussion
- Preliminary study:
- No mortality was recorded in this study. There were no overt signs of systemic toxicity throughout the 14-day observation period and at necropsy. There were no adverse effects on body weights and body weight gains. No gross abnormalities were noted at necropsy.
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- All animals survived.
- Clinical signs:
- other: Following administration, two out of three rats were hypoactive/exhibited piloerection, hunched posture and reduced faecal volume. However, the animals recovered by day 2, appeared active and healthy for the remainder of 14-day observation period.
- Gross pathology:
- No gross abnormalities observed when necropsied at the end of 14-day study.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 of the test substance is greater than 5000 mg/kg of body weight in female rats.
- Executive summary:
The objective of this study was to assess the acute toxicity of Mediator SNP (4-hydroxy-3,5-dimethoxybenzonitrile) when administered as a single oral dose followed by a 14-day period of observation. The information is used for both hazard assessment and ranking purposes. The study was initiated with an initial limit dose of 5000 mg/kg body weight in three female rats. The test substance was administered as a 35% w/w mixture in a 0.5% solution of carboxymethylcellulose (CMC) in distilled water.
No mortality was recorded in this study. There were no overt signs of systemic toxicity throughout the 14-day observation period and at necropsy. There were no adverse effects on body weights and body weight gains. No gross abnormalities were noted at necropsy. Under the conditions of this study, the oral LD50 was >5000 mg/kg body weight.
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