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EC number: 602-927-1 | CAS number: 123312-89-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 15 Jun 1992 to 13 Jul 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 410 (Repeated Dose Dermal Toxicity: 21/28-Day Study)
- Version / remarks:
- May 1981
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 82-2 (Repeated Dose Dermal Toxicity -21/28 Days)
- Version / remarks:
- 1982
- Deviations:
- no
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 6-methyl-4-[(E)-[(pyridin-3-yl)methylidene]amino]-2,3,4,5-tetrahydro-1,2,4-triazin-3-one
- EC Number:
- 602-927-1
- Cas Number:
- 123312-89-0
- Molecular formula:
- C10H11N5O
- IUPAC Name:
- 6-methyl-4-[(E)-[(pyridin-3-yl)methylidene]amino]-2,3,4,5-tetrahydro-1,2,4-triazin-3-one
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- > 1 000 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Remarks on result:
- not determinable due to absence of adverse toxic effects
Target system / organ toxicity
- Critical effects observed:
- no
Any other information on results incl. tables
The content of active ingredient in all samples was found to be in agreement with the nominal concentration. The test article was stable in the vehicle (distilled water) for 5 days at room temperature. During the whole observation period no treatment-related symptoms were observed. Furthermore, signs of local irritation were transient and a dose-response relationship was missing. One female in the 10 mg/kg bw group died, no treatment-related mortality occurred during this study. Bodyweight, food consumption, haematological profile, and blood chemistry parameters investigated were not influenced by the treatment. Organ weights were not affected by the treatment. All macroscopical and microscopical pathology findings were considered to be incidental in nature. In particular, no evidence of dermal toxicity was observed.
Applicant's summary and conclusion
- Conclusions:
- After topical admistration of the test substance to albino rats, it is concluded that the "no observed effect level" (NOEL) for the test substance in this study is higher than the limit dose of 1000 mg/kg bw.
- Executive summary:
In the present study albino rats (Tif: RAif (SPF)) were dermally exposed to 0, 10, 100 and 1000 mg/kg bw per exposure to the test compound. The control group was exposed to vehicle (distilled water) only. Each group consisted of 5 animals per sex. The test article/vehicle suspension was applied under occlusive dressing to the shaved back skin for a period of 4 weeks on a 5 day /week basis. The exposure period was 6 hours per day.The dressings were removed after 6 hours and the application areas were cleaned with lukewarm water.Control analysis of the test article concentration in the vehicle was carried out at all dose levels. The animals were checked for clinical signs and mortality on daily basis. Approximately 17 hours after removing the gauze patches, local skin reactions at the application site of the test article were evaluated according to Draize method. Body weights, food consumption were recorded weekly.Laboratory investigations (haematology, blood chemistry) were carried out on all surviving animals of each dose group at the end of the treatment period. At the end of the test period the surviving controls and treated animals were bled under ether anaesthesia and subjected to detailed autopsy. Organ samples were prepared and subjected to a microscopical examination.
The content of active ingredient in all samples was found to be in agreement with the nominal concentration. The test article was stable in the vehicle (distilled water) for 5 days at room temperature. During the whole observation period no treatment-related symptoms were observed. Furthermore, signs of local irritation were transient and a dose-response relationship was missing. One female in the 10 mg/kg bw group died, no treatment-related mortality occurred during this study. Bodyweight, food consumption, haematological profile, and blood chemistry parameters investigated were not influenced by the treatment. Organ weights were not affected by the treatment. All macroscopical and microscopical pathology findings were considered to be incidental in nature. In particular, no evidence of dermal toxicity was observed.
It is concluded that the "no observed effect level" (NOEL) for the test substance in this study is higher than the limit dose of 1000 mg/kg bw.
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