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Diss Factsheets
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EC number: 244-121-9 | CAS number: 20941-65-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
Due to methodological deficiencies, carcinogenic potential of the test substance could not be determined.
Key value for chemical safety assessment
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
No reliable data on carcinogenicity of the substance are available for assessment.
Additional information
In a pre-GLP and pre-OECD carcinogenicity study (NCI, 1979), 50 rats per sex, were orally exposed (feed) to 150, 300 and 600 ppm of the test substance for 105 weeks, along with 20 control animals for each sex. Animals were observed twice daily. All surviving animals were killed after treatment and pathologic evaluation of gross and microscopic examination of major tissues was performed. No carcinogenic effects were observed in the female rat. Equivocal results were observed in the male rat. The study is considered not reliable (reliability 3) due to methodological deficiencies (exceeded MTD, control group too small).
In a pre-GLP and pre-OECD carcinogenicity study (NCI, 1979), 50 mice per sex, were orally exposed (feed) to 1255, 2132, 3132 or 4915 ppm (time-weighted average dose) of the test substance for 106 weeks, along with 20 control animals for each sex. Animals were observed twice daily. All surviving animals were killed after treatment and pathologic evaluation of gross and microscopic examination of major tissues was performed. Equivocal carcinogenic effects were observed in the male and female mice. The study is considered not reliable (reliability 3) due to methodological deficiencies (exceeded MTD, control group too small, non-malignant tumours).
In a pre-GLP and pre-OECD carcinogenicity study (NTIS, 1968), 18 rats per sex per strain (2 strains), were orally exposed (gavage and feed) to 46.6 mg/kg bw/day of the test substance for 78 weeks, along with 18 control animals for each sex per strain. Animals were observed daily. All surviving animals were killed after treatment and pathologic evaluation was performed. Significant increases in pulmonary ademonas and hepatomas were observed. The study is considered not reliable (reliability 3) due to methodological deficiencies (treatment too short, treatment groups too small, control group too small).
In a pre-GLP and pre-OECD carcinogenicity study (NTIS, 1968), 18 rats per sex per strain (2 strains), were subcutaneously exposed to one injection of 1000 mg/kg bw of the test substance, along with 18 control animals for each sex per strain. Animals were observed daily. All surviving animals were killed after treatment and pathologic evaluation was performed. No significant carcinogenic effecs were observed. The study is considered not reliable (reliability 3) due to methodological deficiencies (unusual treatment, treatment groups too small, control group too small).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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