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EC number: 948-020-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 September 1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-(octyldisulfanyl)octane; 2-(octyldisulfanyl)-5-[(octylsulfanyl)disulfanyl]-1,3,4-thiadiazole; 2-(octyldisulfanyl)-5-{[5-(octyldisulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-1,3,4-thiadiazole; bis(octyldisulfanyl)-1,3,4-thiadiazole
- EC Number:
- 948-020-7
- Molecular formula:
- N/A
- IUPAC Name:
- 1-(octyldisulfanyl)octane; 2-(octyldisulfanyl)-5-[(octylsulfanyl)disulfanyl]-1,3,4-thiadiazole; 2-(octyldisulfanyl)-5-{[5-(octyldisulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-1,3,4-thiadiazole; bis(octyldisulfanyl)-1,3,4-thiadiazole
- Test material form:
- liquid
- Details on test material:
- EC Number: 948-020-7
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: External
- Age at study initiation: Young adult
- Fasting period before study:
- Housing: The rabbits were individually housed in wire mesh bottom cages in an environment controlled room
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: A minimum of 5 days
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Immediately after application, the trunk of each animal was wrapped with an occlusive binder that consisted of a layer of plastic wrap and a stockinette sleeve all secured in place with masking tape.
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 per sex per dose
- Details on study design:
- At the end of 24 hours, the occlusive binders were removed and the exposure sites were gently wiped with clean gauze to remove as much non-·absorbed test article as possible. The animals were observed for mortality and toxic signs frequently on the day of dosing and twice daily thereafter for 14 days. The animals were weighed prior to initiation of the study and on days 8, 15 or at death.
All animals dying during the 14 day post-dose observation period and those sacrificed at the termination of the study were subjected to a gross necropsy and abnormalities were noted.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals survived the 15 day post- dose observation period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the study, the dermal LD50 of the test material has been determined for both sexes as greater than 2000 mg/kg bw.
- Executive summary:
A study has been performed to determine the acute dermal toxicity of the test material. The study has been conducted under GLP conditions and to OECD guidelines. The study has been given a Klimisch Score of 1. The test material was evaluated for in male and female New Zealand White rabbits. The test material was applied to each of ten rabbits at a level of 2000 mg/kg body weight, followed byocclusive coverage for a 24 hour treatment period. Dressings were removed approximately 24 hours after application and excess test substance was removed. Morbidity, mortality, and clinical signs were recorded twice daily for 14 days. Body weights were recorded prior to initiation of the study and on days 8 and 15. Gross necropsies were performed. All animals survived the 15 day post- dose observation period.Under the conditions of the study, the dermal LD50of the test material has been determined for both sexes as greater than 2000 mg/kg bw. Thetest material is not considered to be toxic when applied dermally to New Zeal and White rabbits
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