Registration Dossier
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EC number: 219-495-1 | CAS number: 2445-76-3
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 Apr 2018 to 09 Jun 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- July 27, 1995
- Deviations:
- yes
- Remarks:
- The maximum difference between two measurements was 16% instead of the criterion of ≤ 15%. Evaluation: The test item probably hydrolyzes and therefore the results are accepted (slightly above 15%).
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- March 04, 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- March 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- Appearance: Clear colourless liquid
Purity/Composition: 99.54%
Test item storage: At room temperature protected from light - Key result
- Water solubility:
- 0.063 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- >= 8 - <= 8.2
- Conclusions:
- The slow-stirring flask method was applied for the determination of the water solubility of Hexyl Propionate.
The water solubility of the test item at 20°C was 0.0631 g/L.
The pH of the aqueous samples was 8.0 to 8.2 - Executive summary:
In this guideline (OECD 105) study, conducted with GLP certification, the water solubility of the test substance was found to be 0.0631 g/l at 20 °C.
Reference
Preliminary Test
The content of test item dissolved in the water sample was 0.0342 g/L.
Main Study
The results for the samples taken at 24, 48 and 72 hours are given in Table 6.
The maximum difference between measurements was 41%, due to possible hydrolysis. Based on this, the water solubility of the test item was given as the mean value of the 24- and 48-hour measurements (maximum difference 16%). This is slightly above the criterion of 15% and therefore the results are accepted.
A small response at the retention time of the test item was detected in the chromatogram of the blank water mixture. It was considered to derive from carry-over in the analytical system since similar responses were found in the analytical blanks.
Table 6
Main study - water solubility of the test item
Stirring time |
Analyzed concentration |
Mean |
Maximum difference |
pH |
|
|
|
|
|
24 |
0.0682 |
0.0631 |
16 |
8.1 |
|
|
|
|
|
48 |
0.0579 |
|
|
8.0 |
|
|
|
|
|
72 |
0.0451 |
|
|
8.2 |
|
|
|
|
|
Description of key information
In this guideline (OECD 105) study, conducted with GLP certification, the water solubility of the test substance was found to be 0.0631 g/l at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 0.063 g/L
- at the temperature of:
- 20 °C
Additional information
Study conducted to recognised testing guidelines with GLP certification.
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