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EC number: 291-768-8 | CAS number: 90480-35-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
For the enpoint of acute toxicity two key studies are available: one for acute oral toxicity and one for acute dermal toxicity. No data are available on acute toxicity via inhalation route. Both studies were performed according to their respective OECD test guidelines and in accordance to GLP.
Acute oral toxicity
The substance is not acute oral toxic. The oral LD50 is > 5000 mg/kg bw.
Acute dermal toxicity
Based on the result of this study, the LD50 value of the test substance was considered to be > 2000 mg/kg in male and female rats under the conditions of this study.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral toxicity
For this endpoint there is 1 study available. The study was according to OECD TG 401 and GLP. 5 male and 5 female rats were given 5000 mg/kg bw once and were observed for 14 days. 3 animals died during the study. Slightly depressed bodyweight gains were recorded for surviving male rats during the first week of observation, but bodyweight gains of the remaining rats were normal.
Clinical signs included pilo-erection, hunched posture, lethargy, a decreased respiratory rate and ptosis. A comatose-like condition was observed in one male rat prior to death and wet fur was seen in two males. Necropsy of the survivors at termination of the study did not reveal any macroscopic abnormalities.
Based on these observations the LD50 is > 5000 mg/kg bw. The substance is not oral acute toxic and should not be classified.
Acute dermal toxicity
For this endpoint there is 1 study available. The study was according to OECD TG 402 and GLP.
The purpose of this study was to assess the potential toxicity and the approximate LD50 value of the test substance following a single dermal application to Sprague-Dawley rats at a dose of 2000 mg/kg and a control group. Each group consisted of 5 males and 5 females. There were no deaths of animals reported nor test substance-related effects observed in clinical signs, body weight data or necropsy findings.
Based on the results of this study, the LD50 is > 2000 mg/kg bw for the test substance in male and female rats and under the conditions of this study.
Justification for classification or non-classification
Acute oral toxicity
According to the EU Regulation No. 1272/2008 on the Classification, Labelling and Packaging of Substances and Mixtures (CLP) the substance is not considered to be classified as acute toxic because the LD50 is > 5000 mg/kg bw.
Acute dermal toxicity
According to the criteria described in EU Regulation No. 1272/2008 on the Classification, Labelling and Packaging of Substances and Mixtures (CLP), the test substance should not be classified as acute toxic as the LD50 is > 2000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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