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EC number: 478-920-0 | CAS number: 457632-32-5
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17. Oct. 2016 - 29. May 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: Knudsen cell
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 6-5-A
- Expiration date of the lot/batch: 09. May 2019
- Productiondate: 09.May 2016
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: stored in a tightly closed vessel at room temperature under dry conditions in the dark
- Stability under test conditions: assumed stable
- Solubility and stability of the test substance in the solvent/vehicle: assumed stable and recently soluble
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: none assumed
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
none - Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: calculated
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: calculated
- Test no.:
- #5
- Temp.:
- 363.2 K
- Vapour pressure:
- 0.002 Pa
- Test no.:
- #6
- Temp.:
- 378.2 K
- Vapour pressure:
- 0.004 Pa
- Test no.:
- #7
- Temp.:
- 393.2 K
- Vapour pressure:
- 0.009 Pa
- Test no.:
- #8
- Temp.:
- 408.2 K
- Vapour pressure:
- 0.017 Pa
- Conclusions:
- The vapour pressure of Nomcort HK-P was determined as 1.37 * 10E-05 Pa at 20°C and 2.1 * 10E-05 Pa at 25 °C.
- Executive summary:
The vapour pressure of Nomcort HK-P was determined following EU A.4 using the effusion method (weight loss).
Vapour pressure was examined at eight different temperatures. Four temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (P).
The graph 1/T vs. log (P) shows a straight line with a correlation coefficient of -0.9998. The vapour pressures at 20 °C and 25 °C were calculated based on the regression equation.:
Vapour pressure at 20 °C: 1.37 * 10E-05 Pa
Vapour pressure at 25 °C: 2.10 * 10E-05 Pa
Reference
Description of key information
OECD Guideline study
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 20 °C
Additional information
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