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EC number: 269-642-9 | CAS number: 68308-30-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
There is only limited data available on the environmental fate of Fatty acids, montan-wax, stearyl esters (CAS 68308-30-5). Therefore, log Koc values for the adsorption potential as well as BCF values for the aquatic bioaccumulation potential were predicted by (Q)SAR calculations.
Fatty acids, montan-wax, stearyl esters (CAS 68308-30-5) is characterized by a molecular weight of 270.49 to 987.74 g/mole, low water solubility (< 0.539 mg/L, 20 °C, OECD 105), low estimated vapour pressure (< 0.0001 Pa, 20 °C, SPARC v5.6) and a high estimated log Koc (> 10.0, KOCWIN v2.00). Furthermore, the substance is not readily biodegradable (28% in 28 d, OECD 301 F). Thus, abiotic degradation via hydrolysis and phototransformation in air are not relevant environmental fate pathways due to low solubility and low vapour pressure, respectively.
If released into the aquatic environment, only low concentrations of the substance are expected to dissolve in the water phase. Rather, the substance is expected to sorb to organic matter, leading to an effective reduction of its bioavailability in the water column. Therefore, sediment and soil are expected to be its main compartments of environmental distribution.
Based on the substance properties and environmental distribution, the most relevant potential route of uptake by aquatic organisms is expected to occur via contact with or ingestion of particle-bound substance. However, its bioavailability in the sediment compartment is presumably very low based on its intrinsic physico-chemical properties (e.g. high sorption). Furthermore, the parent compound is expected to biotransform via enzymatic hydrolysis catalyzed by ubiquitous carboxylesterases. The hydrolysis products (constituent fatty acids and alcohols) are readily absorbed and undergo further metabolization and/or take on vital cellular functions (e.g. energy supply and storage, lipid bilayer formation). Thus, in the case of uptake and absorption by aquatic organisms, long-chain aliphatic esters are expected to be enzymatically hydrolyzed by ubiquitouscarboxylesterases, yielding the corresponding alcohols and fatty acids. Both hydrolysis products are expected to be metabolized and excreted by aquatic organisms. The metabolization of the hydrolysis products in fish is well established and not of concern in terms of bioaccumulation(Heymann, 1980; Lech & Bend, 1980; Lech & Melancon, 1980; Murphy & Lutenske, 1990; Sand et al., 1973).
Experimental data for bioaccumulation is not available for Fatty acids, montan-wax, stearyl esters (CAS 68308-30-5)and the estimated log Kow is high (> 10.0, SPARC v4.6), which may be indicative of a potential for aquatic bioaccumulation. However, the screening value for aquatic bioaccumulation based solely on log Kow presumably overestimates the true bioaccumulation potential of the substance since it does not account for the environmental fate and toxicokinetic behaviour (absorption, distribution metabolization and excretion) of the substance in living organisms. According to current knowledge, a log Kow of 10.0 or above is taken as an indicator of reduced bioconcentration (R.7c and R.11, ECHA, 2017). Substances with log Kow values above 9.3 are generally predicted to have BCF values of maximum 2000 L/kg (R.11, ECHA, 2017). The predicted BCF values for this substance provide additional evidence that the potential for bioaccumulation in aquatic organisms is low. All models consistently predicted very low BCF values of maximally 28.18 L/kg, which are clearly below the threshold values of 2000 L/kg and 5000 L/kg for bioaccumulative and very bioaccumulative substances, respectively, as laid down by REACH Regulation (EC) 1907/2006 (Annex XIII, section 1).
Thus, a significant uptake and bioaccumulation of the substance in aquatic organisms is not expected based on the extremely high log Kow, environmental and toxicokinetic behaviour, as well as on (Q)SAR predictions for bioconcentration.
In summary, in the case of absorption by aquatic organisms, the substance is expected to be rapidly hydrolyzed to the respective fatty acid and fatty alcohol components by ubiquitous carboxylesterases. Based on the available information, the potential for aquatic bioaccumulation of both the substance as well as its metabolites is expected to be low. Thus, the available information on environmental behavior, metabolism and bioaccumulation suggest that the overall potential for aquatic bioaccumulation of the target substance is low. Further information refer to the IUCLID chapters on bioaccumulation as well as on toxicokinetics, metabolism and distribution.
REFERENCES
Heymann, E. (1980): Carboxylesterases and amidases. In: Jakoby, W.B., Bend, J.R. & Caldwell, J., eds., Enzymatic Basis of Detoxication, 2nd Ed., New York: Academic Press, pp. 291-323.
Lech, J., Melancon, M. (1980): Uptake, metabolism, and deposition of xenobiotic chemicals in fish. EPA-600 3-80-082. U.S. Environmental Protection Agency, Duluth, MN, USA.
Lech, J.J. & Bend, J.R. (1980): Relationship between biotransformation and the toxicity and fate of xenobiotic chemicals in fish. Environ. Health Perspec. 34, 115-131.
Murphy, P.G., Lutenske, N.E. (1990): Bioconcentration of haloxyfop-methyl in bluegill (Lepomis macrochirus Rafinesque). Environ. Intern. 16, 219-230.
Sand, D.M., Rahn, C.H., Schlenk, H. (1973): Wax esters in fish: Absorption and metabolism of oleyl alcohol in the gourami (Trichogaster cosby). J Nutr 103: 600-607.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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