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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 48 hours
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- The read-across from Mn salts is justified on the basis that these substances are very soluble in water and both will dissociate to release Mn2+ ions. The anions are not considered to have any influence on the effective toxicity of Mn2+ and as demonstrated with the algal study, the toxicity of the substance to invertebrates can be estimated based on known effects of Mn 2+ metal
- Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Principles of method if other than guideline:
- Principles of method followed, but using different species
Up to 96 hours acute test on < 24 hr old organisms.
Toxicity examined in three different levels of hardness - GLP compliance:
- not specified
- Remarks:
- Academic research
- Analytical monitoring:
- yes
- Details on sampling:
- Samples at start and end of testing on highest and lowest concentrations
- Vehicle:
- no
- Test organisms (species):
- Ceriodaphnia dubia
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- Three levels of hardness:
Soft = 26 mg/l
Medium = 92 mg/l
Hard = 184 mg/l - Test temperature:
- 25 C
- pH:
- 8 - 8.4
- Nominal and measured concentrations:
- Nominal Concentrations 2.5, 5, 10, 20, 40, 80 mg/l as Mn 2+
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 34 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Remarks:
- Estimated for Manganese glycinate based on Mn toxicity
- Basis for effect:
- mobility
- Remarks on result:
- other: Medium water (ie within guideline level)
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 13.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Remarks:
- Mn 2+
- Basis for effect:
- mobility
- Remarks on result:
- other: Hard water
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 8.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Remarks:
- Mn 2+
- Basis for effect:
- mobility
- Remarks on result:
- other: Medium hardness
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Remarks:
- Mn
- Basis for effect:
- mobility
- Remarks on result:
- other: Soft water
- Details on results:
- Important to note that the toxicity was greatest in the soft water.
This is in line with fish toxicity testing - Validity criteria fulfilled:
- not specified
- Conclusions:
- The toxicity to Manganese was greatest in soft water and confirms toxicity vs hardness relationship seen with fish.
Reference
Description of key information
The aquatic toxicity for the target is predicted at level EC50 34 mg/l based on the toxic effect of Mn
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- ca. 34 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.