Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-533-0 | CAS number: 17540-75-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
Data source
Materials and methods
Results and discussion
Any other information on results incl. tables
SR08226 - Summarization
Oral doses of 4 -sec-butyl-2,6 -Di-tert-butylphenol by 0 (corn oil as control), 15, 60 and 250 mg/kg/day were applied to a group of Crl:CD(SD) rats consisting of 6 males and 6 females for 28 days to find out if or not it is toxic to the rat. Furthermore, for the doses of 0 and 250 mg/kg/day, a recovery group consisting of 6 males and 6 females were continuously observed for 14 days from the day following the last day of dosing.
The study gave the following results:
1. Under general status, both males and females are recognized with loose stool in case of the 250mg/kg dose group.
2. During the urine examination, the males in the 250mg/kg dose group are recognized to show significantly low urine pH values.
3. During blood examination, prothrombin time in case of the males in the group with dose beyond 60mg/kg, and thromboplastin time of the activated part in case of the males in the groups with doses beyond 60mg/kg and the females in the 250mg/kg dose group are recognized to be significantly extended.
4. During blood chemical examination, total cholesterin is recognized to have a significantly high value in case of the females in the groups with doses beyond 15mg/kg and the males in the groups with doses beyond 60mg/kg, the total bilirubinis recognized to have a significant high value in case of both males and females in the 250mg/kg dose group and AST, ALT, alkaline phosphatase and urea nitrogen are recognized to have significant high values while kalium and inorganic phosphorus are recognized to have significant low values in case of males, and the fraction ratio of α1-blobulin and creatinine are recognized to have significantly high values in case of females.
5. According to the anatomic examination, the watery content of caecum is recognized in case of the males in the 60mg/kg dose group, and both males and females in the 250mg/kg dose group.
6. For the organ weight, the relative weight of liver is recognized to have a significant high value in case of the females in the group with dose beyond 15mg/kg and the absolute weight is recognized to have a significant high value in case of the females in the 250mg/kg dose group.
7. According to the histopathologic examination, slight centrilobular liver cell hypertrophy is recognized in case of the females in the 250mg/kg dose group.
8. It is recognized that any of the changes recognized by 1-7 will get recovered.
9. No change related to the dose of test substance is recognized in detailed status observation, function inspection, weight and intake volume.
Therefore, the amount of 4-sec-butyl-2,6-Di-tert-butylphenol which will not deliver any impact (NOEL) is considered to be 15mg/kg/day in case of males and less than 15mg/kg/day in case of females under the conditions of this test.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.