Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 226-952-9 | CAS number: 5577-13-9
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP. Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil
Test material
- Reference substance name:
- Ethyl [(4-methylphenyl)sulphonyl]carbamate
- EC Number:
- 226-952-9
- EC Name:
- Ethyl [(4-methylphenyl)sulphonyl]carbamate
- Cas Number:
- 5577-13-9
- Molecular formula:
- C10H13NO4S
- IUPAC Name:
- ethyl [(4-methylphenyl)sulfonyl]carbamate
- Details on test material:
- The principle of the test method is similar to that of the OECD guiderline no. 117: "Partition coefficient (n-octanol/water), high performance liquid chromatography (HPLC) method".
Constituent 1
Study design
- Test temperature:
- Column temperature: 35ºC <> 1ºC
Results and discussion
Adsorption coefficientopen allclose all
- Type:
- log Koc
- Remarks:
- at neutral pH
- Value:
- < 1.26
- Type:
- Koc
- Value:
- < 18
- Type:
- log Koc
- Remarks:
- at pH2
- Value:
- 1.38
- Type:
- Koc
- Value:
- 24
Any other information on results incl. tables
HPLC method at neutral pH:
In the chromatogram of the test substance solution, one peak with a retention time of 1.66 minutes was observed. Under the same analytical conditions, the retention time of acetanilide (log Koc=1.26) was 2.20 minutes. Hence, it was concluded that the log Koc of test substance was <1.26 (Koc<18).
Applicant's summary and conclusion
- Conclusions:
- The HPLC method at pH 2 and neutral pH and using soil-adsorption-reference data was applied fot the determination of the adsorption coefficient (Koc) of Tolfamato.
The Koc and log Koc value of the test substance and impurities at neutral ph and pH 2 was:
-At neutral pH: Koc <18; log Koc <1.26
-At pH 2: Koc=24; log Koc= 1.38
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
