Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 304-059-6 | CAS number: 94233-27-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- 2-ethylhexanol and pentane-2,4-dione are two main hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Zur Toxizität einiger C8-Aldehyde und -Alkohole
- Author:
- Schmidt, P.; Gohlke, R.; Rothe, R
- Year:
- 1 973
- Bibliographic source:
- Zeitschrift für die gesamte Hygiene, 19, 1973, 485-490, cited in BG-Chemie, 1995
- Reference Type:
- publication
- Title:
- 2-Ethylhexanol
- Author:
- BG-Chemie
- Year:
- 1 995
- Bibliographic source:
- Toxikologische Bewertungen, Programm zur Verhütung von Gesundheitsschädigungen durch Arbeitsstoffe
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2-ethylhexan-1-ol
- EC Number:
- 203-234-3
- EC Name:
- 2-ethylhexan-1-ol
- Cas Number:
- 104-76-7
- Molecular formula:
- C8H18O
- IUPAC Name:
- 2-ethylhexan-1-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 330, 660 and 1320 mg/kg bw
- No. of animals per sex per dose:
- Not specified
- Details on study design:
- Substance was administered 5 days/week. Duration of observation:
Doage level 330 or 660 mg/kg bw /day : 17 days.
Dosage level 1320 mg/kg bw /day : 22 days.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 290 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 870 - 3 790
- Mortality:
- 2 rats died at the high dose leve.
- Other findings:
- Animals died in narcosis with no other findings.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The oral LD50 on rats was 3290 mg/kg bw, and was classified as Category 5 according ly GHS criteria.
- Executive summary:
As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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