Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-301-1 | CAS number: 111870-68-9 1 - 6.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 January 2018 to 27 January 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1075 (Freshwater and Saltwater Fish Acute Toxicity Test)
- Qualifier:
- according to guideline
- Guideline:
- other: Japanese Ministry of Agriculture, Forestry and Fisheries, Test Data for Registration of Agricultural Chemicals, 12 Nohsan No 8147, Agricultural Production Bureau, November 24, 2000. Acute fish toxicity 2-7-1.
- Principles of method if other than guideline:
- no analytics were performed in absence of an analytical method suitable to measure the substance
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- A primary stock concentrate of the substance, with a nominal concentration of 10 g/L, was prepared by weighing a nominal 0.1 g of test substance (actual weight: 0.10008 g) into a weigh boat and rinsing into a 10 mL volumetric flask with tetrahydrofuran (THF) and making up to 10 mL volume. The concentrate was then manually shaken to mix. The resultant stock was observed to be clear and colourless and was used to prepare the test solution.
Total amount of THF present in the test solutions 100 ug/L. - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Source: Houghton Springs Fish Farm, Blandford Forum, DT11 OPD
- Age at study initiation (mean and range, SD): no data
- Length at study end (range): 54 – 57 mm
- Weight at study end (range): 2.09 – 2.50 g
- Loading rate: 1.7 g/L
ACCLIMATION
- Acclimation period: 7 days
- Acclimation conditions: held in a fibreglass tank under artificial lighting and were contained in water as described for the test dilution water. They were held at 15 ±1°C and were fed daily using a commercial fish food.
- Health during acclimation: no mortality
FEEDING DURING TEST : none - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 74.0 mg/L as CaCO3
- Test temperature:
- 15.0-16.0 °C
- pH:
- 7.23-7.93
- Dissolved oxygen:
- 8.59-9.85 mg/L
- Nominal and measured concentrations:
- nominal: 0 and 1.0 mg/L (additional vehicle control)
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 15 L moulded glass tank
- Type (delete if not applicable): closed
- Fill volume: 10 L
- Aeration: no
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
- Biomass loading rate: 1.7 g/L (end of test)
TEST MEDIUM / WATER PARAMETERS : tap water which had been coarsely filtered to remove particulate material, passed through activated carbon and dechlorinated using sodium thiosulphate. Salts were added, as required, to maintain minimum hardness levels, and the treated water passed through an ultraviolet steriliser and filtered to 10 µm.
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16/8
EFFECT PARAMETERS MEASURED: mortality and symptoms of toxicity at 3, 24, 48, 72 and 96 hours
TEST CONCENTRATIONS : derived from the results of a Daphnia sp. acute immobilisation test and an algal toxicity test. According to the OECD Threshold Approach, the lowest EC50 value from these studies was set as the threshold concentration for a limit test as described in OECD TG 203
- Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- The loading rate was higher than prescribed by the guideline. This was evaluated to have had no effect on the results as oxygen concentrations in the aquaria were above saturation level and did not drop during the cause of the study.
- Reported statistics and error estimates:
- NA
- Sublethal observations / clinical signs:
No analytical determination of the concentrations was possible in absence of a suitable analytical method. The substance is a complex UVCB and despite efforts no analytical method could be found.
mortalities and symptoms of toxicity
Nominal concentration
Cumulative percentage mortality observed
(mg/L)
3 hour
24 hour
48 hour
72 hour
96 hour
Control
0
0
0
0
0
Solvent Control
0
0
0
0
0
1.0
0
0
0
0
0
Seven fish were exposed in each test vessel
No symptoms of toxicity were observed.
- Validity criteria fulfilled:
- yes
- Remarks:
- with the exemption of the analytical verification of the doses
- Conclusions:
- The LC50 of the substance in fish is > 1.0 mg/L
- Executive summary:
Subject
Determination of acute toxicity to rainbow trout (Oncorhynchus mykiss)
Guideline
OECD 203
Test species
Rainbow trout (Oncorhynchus mykiss)
Source of organisms
Houghton Springs Fish Farm, Blandford Forum, DT11 OPD
Test concentrations
Control, Solvent Control and a nominal concentration of 1.0 mg/L.
Length of test
96 hours, Static
Nominal
test temperature
15±1°C
Results based on nominal concentrations
Time
LC50
Calculation method
24 hours
>1.0 mg/L
Direct observation of the data
48 hours
>1.0 mg/L
Direct observation of the data
72 hours
>1.0 mg/L
Direct observation of the data
96 hours
>1.0 mg/L
Direct observation of the data
Based on absence of mortaility compared to the control, the 96 hour No Observed Effect Concentration (NOEC) was determined to be 1.0 mg/L and the Lowest Observed Effect Concentration (LOEC) was >1.0 mg/L.
Reference
Description of key information
In a limit test with a structurally similar substance at 1.0 mg/L rainbow trouts were exposed for 96 hours in a static test according to OECD 203. Based on absence of mortality and signs of toxicity compared to the control, the 96 hour NOEC was determined to be 1.0 mg/L and the LC50 was >1.0 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 mg/L
Additional information
No studies on Castor oil, hydrogenated, propoxylated are available. In view of the structural and physico-chemical similarities between the source and the target chemical, the toxicity of Castor oil, hydrogenated, ethoxylated is considered to be representative for the toxicity of the target substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.