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EC number: 230-939-3 | CAS number: 7378-99-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04/01/1980-08/02/1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- Study conducted before OECD 402 was in existence. The LD 50 was calculated according to the method of Litchfield
J.T. Jr. & F. Wilcoxon (J. Pharm. & Exp. Therap. 96:99, 1949), or Horn, H.J.
Biometrics 12:311, 1956.
- Principles of method if other than guideline:
- Study conducted before OECD 402 was in existence.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dimethyl(octyl)amine
- EC Number:
- 230-939-3
- EC Name:
- Dimethyl(octyl)amine
- Cas Number:
- 7378-99-6
- Molecular formula:
- C10H23N
- IUPAC Name:
- dimethyl(octyl)amine
- Details on test material:
- Name: AD 1
Chemical Name: N, N-Dimethyloctylamine
CAS No.: 7378-99-6
Batch No.: 13602808
Expiry Date: not applicable
Physical State at Room Temperature: liquid
Colour: clear
Volatility: volatile
Density: 0.765
Molecular Weight: 157.3
Active Components: > 95%
Structure Formula of
Active Component: C8H17-N-(CH3)2
Storage Conditions: at room temperature
Constituent 1
- Specific details on test material used for the study:
- ADMA C8
Clear liquid, specific gravity 0.76 g/L
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- New Zealand White rabbits, approximately 8 weeks old when received, were equilibrated for at least one week in this laboratory. Apparently healthy rabbits were selected for the test. The animals were identified by cage tags noting the test material, starting date, animal number and sex. In addition, odd numbered animals in each cage were identified with an indelible ear mark. The animals were housed 2/cage in suspended wire mesh cages (30 11 x 18" x 1811). Fresh Purina rabbit chow and water were freely available. The animal room reserved exclusively for rabbits on acute tests, was maintained at 20 - 21 0 C and was kept clean in accordance with the standards of AAALAC of which this laboratory is an approved member.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The test material was applied once dermally to the prepared site under gauze patches. The patches were secured with adhesive tape and the trunks were wrapped with impervious material.
- Duration of exposure:
- The test material was kept in contact with the skin for 24 hours, at which time the wrappings were removed. An estimate of the amount of material remaining was recorded.
- Doses:
- 20,000 mg/kg - group 1
16,000 mg/kg - group 2
4,000 mg/kg - group 3
1,000 mg/kg - group 4 - No. of animals per sex per dose:
- 2 male/ 2 female - group 1
4 female - group 2
4 male - group 3
4 male - group 4 - Control animals:
- no
- Details on study design:
- A limit test was performed in which group one of two male and two female rabbits received a single dermal administration of the test article at a dose of 20,000 mg/kg body weight. Following dosing, all 4 rats died within 90 minutes therefore 3 additional groups of four rabbits were dosed at log intervals in an attempt to determine the LD 50. Doses were selected in an attempt to achieve at least two "partial kills"and if possible a "zero kill" and/or a "100% kill".
Dermal reactions were scored at 24 hours by the Draize scoring system. The rabbits were observed daily for14 days for signs of toxicity, pharmacological effects and mortality. Body weights were recorded
pretest and in the survivors at 14 days. If there were deaths duri ng the study, all animals in the high dose group were examined for gross pathol ogy. In the lower dose levels, only animals which died during the study were examined for gross pathology. - Statistics:
- The LD 50, if possible, was calculated according to the method of Litchfield J.T. Jr. & F. Wilcoxon (J. Pharm. & Exp. Therap. 96:99, 1949), or Horn, H.J. Biometrics 12:311, 1956.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- approximate LD50
- Effect level:
- 4 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0/4, 2/4, 4/4 and 4/4 animals died using this test substance at dose levels of 1,000, 4,000, 16,000 and 20,000 mg/kg of body weight respectively.
- Clinical signs:
- other: Skin reactions were pronounced; erythema was generally severe while edema was mostly moderate. The most common toxic sign was lethargy.
- Gross pathology:
- Animals dying before Day 14 had respiratory, cardiac and skin abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The test article, when administered by dermal to male New Zealand White rabbits, has an estimated acute dermal LD50 of 4,000 mg/kg bw
- Executive summary:
The test article, N,N-dimethyloctan-1-amine, was administered once dermally to the prepared site under gauze patches of male/female New Zealand White rabbits at varying test item concentrations. has an estimated acute dermal LD50 of 4,000 mg/kg bw.
0/4, 2/4, 4/4 and 4/4 animals died using this test substance at dose levels of 1,000, 4,000, 16,000 and 20,000 mg/kg of body weight respectively.
Skin reactions were pronounced; erythema was generally severe while edema was mostly moderate. The most common toxic sign was lethargy. Several surviving animals lost considerable amounts of weight.
Animals dying before Day 14 had respiratory, cardiac and skin abnormalities. The estimated acute dermal LD50 was determined to be 4,000 mg/kg bw.
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